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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8TQC

Structure of the human CDK8 kinase module

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0006351biological_processDNA-templated transcription
A0006468biological_processprotein phosphorylation
A0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
A0016301molecular_functionkinase activity
A0016592cellular_componentmediator complex
A0016740molecular_functiontransferase activity
A0032991cellular_componentprotein-containing complex
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0051726biological_processregulation of cell cycle
A0106310molecular_functionprotein serine kinase activity
A1990508cellular_componentCKM complex
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0006351biological_processDNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
B0016592cellular_componentmediator complex
B0042802molecular_functionidentical protein binding
B0045023biological_processG0 to G1 transition
B0045746biological_processnegative regulation of Notch signaling pathway
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B1990508cellular_componentCKM complex
C0000151cellular_componentubiquitin ligase complex
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0003682molecular_functionchromatin binding
C0003712molecular_functiontranscription coregulator activity
C0003713molecular_functiontranscription coactivator activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0006351biological_processDNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0008013molecular_functionbeta-catenin binding
C0016020cellular_componentmembrane
C0016567biological_processprotein ubiquitination
C0016592cellular_componentmediator complex
C0042809molecular_functionnuclear vitamin D receptor binding
C0045893biological_processpositive regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046966molecular_functionnuclear thyroid hormone receptor binding
C0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
C0061630molecular_functionubiquitin protein ligase activity
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0003712molecular_functiontranscription coregulator activity
D0003713molecular_functiontranscription coactivator activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0006351biological_processDNA-templated transcription
D0006357biological_processregulation of transcription by RNA polymerase II
D0016020cellular_componentmembrane
D0016592cellular_componentmediator complex
D0042632biological_processcholesterol homeostasis
D0042809molecular_functionnuclear vitamin D receptor binding
D0045893biological_processpositive regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046966molecular_functionnuclear thyroid hormone receptor binding
D0060261biological_processpositive regulation of transcription initiation by RNA polymerase II
D0070328biological_processtriglyceride homeostasis
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues26
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK
ChainResidueDetails
AVAL27-LYS52
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV
ChainResidueDetails
AVAL147-VAL159
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues47
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues19
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"A2AGH6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsMotif: {"description":"LXXLL motif 1"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsMotif: {"description":"LXXLL motif 2"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues14
DetailsRegion: {"description":"Interaction with CCNC"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues98
DetailsDomain: {"description":"Cyclin N-terminal"}
ChainResidueDetails

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PDB entries from 2025-12-17

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