8TQ8
Crystal structure of Fab.34.5.8 in complex with MHC-I (H2-Dd)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | H-2 class I histocompatibility antigen, D-D alpha chain | polymer | 273 | 31819.4 | 2 | UniProt (P01900) Pfam (PF00129) Pfam (PF07654) In PDB | Mus musculus (house mouse) | MHC-I H2-Dd A chain |
| 2 | B, D | Beta-2-microglobulin | polymer | 99 | 11704.4 | 2 | UniProt (P01887) Pfam (PF07654) In PDB | Mus musculus (house mouse) | |
| 3 | P, E | Transmembrane protein gp41 | polymer | 10 | 1075.3 | 2 | UniProt (P04578) In PDB | Human immunodeficiency virus 1 | TM,Glycoprotein 41,gp41 |
| 4 | H, F | Fab.34.5.8 Heavy chain | polymer | 219 | 23325.1 | 2 | Mus musculus (mouse) | ||
| 5 | L, G | Fab.34.5.8 Light chain | polymer | 219 | 24207.7 | 2 | Mus musculus (mouse) | ||
| 6 | A, H, D | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 7 | B, C, F | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 8 | water | water | 18.0 | 123 | Chemie (HOH) |
Sequence modifications
B, D: 1 - 99 (UniProt: P01887)
| PDB | External Database | Details |
|---|---|---|
| Asp 85 | Ala 105 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 184263.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 646.7 | |
| All* | Total formula weight | 184910.3 |
