8TPW

Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: cis-oriented 1B2 and ACP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E (A, B, C)	EryAII,EryAII,EryAII,EryAII,6-deoxyerythronolide-B synthase EryA3, modules 5 and 6	polymer	1766	186489.6	3	UniProt (Q5UNP5) Pfam (PF08990) Pfam (PF00109) Pfam (PF02801) Pfam (PF16197) Pfam (PF00698) Pfam (PF08659) Pfam (PF00550) UniProt (by SIFTS) (Q03132)	Saccharopolyspora erythraea
2	C (H)	Antibody Fragment 1B2, Heavy Chain	polymer	249	26447.6	1		Homo sapiens (human)
3	D (L)	Antibody Fragment 1B2, Light Chain	polymer	236	25715.8	1		Homo sapiens (human)

Sequence modifications

A, B, C: 3 - 1466 (UniProt: Q5UNP5)

PDB	External Database	Details
Met 0	-	expression tag
Ala 1	-	expression tag
Ser 2	-	expression tag
Thr 481	Ser 480	conflict

A, B, C: 1467 - 1765 (PDB: 8TPW)

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	611632.2
All*	Total formula weight	611632.2

*Water molecules are not included.