8TPW
Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: cis-oriented 1B2 and ACP
Functional Information from PROSITE/UniProt
site_id | PS00178 |
Number of Residues | 11 |
Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Pv.TAlVHAGTL |
Chain | Residue | Details |
A | PRO1200-LEU1210 |
site_id | PS00213 |
Number of Residues | 12 |
Details | LIPOCALIN Lipocalin signature. ESG..NLDGDWLVV |
Chain | Residue | Details |
A | GLU933-VAL944 |
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
Chain | Residue | Details |
H | TYR201-HIS207 | |
L | TYR214-HIS220 |
site_id | PS00606 |
Number of Residues | 17 |
Details | KS3_1 Ketosynthase family 3 (KS3) active site signature. GPSisVDtACSSSlvAL |
Chain | Residue | Details |
A | GLY194-LEU210 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | ACT_SITE: Acyl-thioester intermediate; for beta-ketoacyl synthase 1 activity => ECO:0000255|PROSITE-ProRule:PRU01348, ECO:0000305|PubMed:17719492 |
Chain | Residue | Details |
A | CYS203 | |
B | CYS203 | |
C | CYS221 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | ACT_SITE: For beta-ketoacyl synthase 1 activity => ECO:0000255|PROSITE-ProRule:PRU01348 |
Chain | Residue | Details |
A | HIS338 | |
A | HIS378 | |
B | HIS338 | |
B | HIS378 | |
C | HIS356 | |
C | HIS396 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | ACT_SITE: Acyl-ester intermediate; for acyltransferase 1 activity => ECO:0000255|PROSITE-ProRule:PRU10022 |
Chain | Residue | Details |
A | SER652 | |
B | SER652 | |
C | SER670 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | ACT_SITE: For C2-type beta-ketoacyl reductase 1 and probable racemase activity => ECO:0000250|UniProtKB:Q9ZGI4, ECO:0000305|PubMed:21570406 |
Chain | Residue | Details |
A | TYR1268 | |
B | TYR1268 | |
C | TYR1286 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | SITE: Important for substrate specificity of the beta-ketoacyl synthase 1 => ECO:0000305|PubMed:17719492 |
Chain | Residue | Details |
A | LYS156 | |
A | PHE157 | |
B | LYS156 | |
B | PHE157 | |
C | LYS174 | |
C | PHE175 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | MOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255|PROSITE-ProRule:PRU00258 |
Chain | Residue | Details |
A | 4HH1431 | |
B | 4HH1431 | |
C | 4HH1449 |