8TM7

Human NAMPT in complex with substrate NAM and small molecule activator NP-A3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Nicotinamide phosphoribosyltransferase	polymer	499	56666.1	2	UniProt (P43490) Pfam (PF18127) Pfam (PF04095)	Homo sapiens (human)	NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	C, D (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
3	E, K (A, B)	NICOTINAMIDE	non-polymer		122.1	2	Chemie (NCA)
4	F, L (A, B)	N-{2-[(4R)-2,2-dimethyl-4-(propan-2-yl)oxan-4-yl]ethyl}-N-[(4-methoxyphenyl)methyl]furan-2-carboxamide	non-polymer		413.6	2	Chemie (I7Q)
5	G, H, I (A)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
6	J, M (A, B)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
7	N, O (A, B)	water	water		18.0	435	Chemie (HOH)

Sequence modifications

A, B: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
Leu 492	-	expression tag
Glu 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	113332.2
Non-Polymers*	Number of molecules	11
	Total formula weight	1551.8
All*	Total formula weight	114884.0

*Water molecules are not included.