8TM7
Human NAMPT in complex with substrate NAM and small molecule activator NP-A3
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Nicotinamide phosphoribosyltransferase | polymer | 499 | 56666.1 | 2 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB | Homo sapiens (human) | NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin |
2 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
3 | A, B | NICOTINAMIDE | non-polymer | 122.1 | 2 | Chemie (NCA) | |||
4 | A, B | N-{2-[(4R)-2,2-dimethyl-4-(propan-2-yl)oxan-4-yl]ethyl}-N-[(4-methoxyphenyl)methyl]furan-2-carboxamide | non-polymer | 413.6 | 2 | Chemie (I7Q) | |||
5 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
6 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
7 | water | water | 18.0 | 435 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 491 (UniProt: P43490)
PDB | External Database | Details |
---|---|---|
Leu 492 | - | expression tag |
Glu 493 | - | expression tag |
His 494 | - | expression tag |
His 495 | - | expression tag |
His 496 | - | expression tag |
His 497 | - | expression tag |
His 498 | - | expression tag |
His 499 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 113332.2 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 1551.8 | |
All* | Total formula weight | 114884.0 |