8TM0

Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	NKG2-D type II integral membrane protein	polymer	264	30432.4	1	UniProt (P26718) Pfam (PF00059) In PDB	Homo sapiens (human)	Killer cell lectin-like receptor subfamily K member 1,NK cell receptor D,NKG2-D-activating NK receptor
2	C	MHC class I polypeptide-related sequence A	polymer	188	22144.8	1	UniProt (Q29983) Pfam (PF00129) In PDB	Homo sapiens (human)
3	B	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A: 3 - 135 (UniProt: P26718)

PDB	External Database	Details
Gly 1	-	expression tag
Ser 2	-	expression tag

A: 136 - 264 (UniProt: P26718)
C: 1 - 182 (UniProt: Q29983)

PDB	External Database	Details
Trp 69	Asn 92	conflict
Leu 125	Lys 148	conflict
Glu 152	Lys 175	conflict
Asp 154	Lys 177	conflict
Arg 161	His 184	conflict
Ser 166	Gln 189	conflict
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52577.3
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	53222.9

*Water molecules are not included.