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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8TLD

Structure of the IL-5 Signaling Complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1B, ECytokine receptor common subunit betapolymer71781078.82UniProt (P32927)
Pfam (PF21460)
In PDB		Homo sapiens (human)CDw131,GM-CSF/IL-3/IL-5 receptor common beta subunit
2C, DInterleukin-5polymer14616836.12UniProt (P05113)
Pfam (PF02025)
In PDB		Homo sapiens (human)
3FInterleukin-5 receptor subunit alphapolymer39244590.21UniProt (Q01344)
Pfam (PF09240)
In PDB		Homo sapiens (human)
4C, F2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.25Chemie (NAG)
Sequence modifications
B, E: 23 - 439 (UniProt: P32927)
PDBExternal DatabaseDetails
Asp -234-expression tag
Tyr -233-expression tag
Lys -232-expression tag
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Val -225-expression tag
Ser -224-expression tag
Lys -223-expression tag
Gly -222-expression tag
Glu -221-expression tag
Glu -220-expression tag
Leu -219-expression tag
Phe -218-expression tag
Thr -217-expression tag
Gly -216-expression tag
Val -215-expression tag
Val -214-expression tag
Pro -213-expression tag
Ile -212-expression tag
Leu -211-expression tag
Val -210-expression tag
Glu -209-expression tag
Leu -208-expression tag
Asp -207-expression tag
Gly -206-expression tag
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Val -204-expression tag
Asn -203-expression tag
Gly -202-expression tag
His -201-expression tag
Lys -200-expression tag
Phe -199-expression tag
Ser -198-expression tag
Val -197-expression tag
Ser -196-expression tag
Gly -195-expression tag
Glu -194-expression tag
Gly -193-expression tag
Glu -192-expression tag
Gly -191-expression tag
Asp -190-expression tag
Ala -189-expression tag
Thr -188-expression tag
Tyr -187-expression tag
Gly -186-expression tag
Lys -185-expression tag
Leu -184-expression tag
Thr -183-expression tag
Leu -182-expression tag
Lys -181-expression tag
Phe -180-expression tag
Ile -179-expression tag
Cys -178-expression tag
Thr -177-expression tag
Thr -176-expression tag
Gly -175-expression tag
Lys -174-expression tag
Leu -173-expression tag
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Val -171-expression tag
Pro -170-expression tag
Trp -169-expression tag
Pro -168-expression tag
Thr -167-expression tag
Leu -166-expression tag
Val -165-expression tag
Thr -164-expression tag
Thr -163-expression tag
Leu -162-expression tag
Thr -161-expression tag
Tyr -160-expression tag
Gly -159-expression tag
Val -158-expression tag
Gln -157-expression tag
Cys -156-expression tag
Phe -155-expression tag
Ser -154-expression tag
Arg -153-expression tag
Tyr -152-expression tag
Pro -151-expression tag
Asp -150-expression tag
His -149-expression tag
Met -148-expression tag
Lys -147-expression tag
Gln -146-expression tag
His -145-expression tag
Asp -144-expression tag
Phe -143-expression tag
Phe -142-expression tag
Lys -141-expression tag
Ser -140-expression tag
Ala -139-expression tag
Met -138-expression tag
Pro -137-expression tag
Glu -136-expression tag
Gly -135-expression tag
Tyr -134-expression tag
Val -133-expression tag
Gln -132-expression tag
Glu -131-expression tag
Arg -130-expression tag
Thr -129-expression tag
Ile -128-expression tag
Phe -127-expression tag
Phe -126-expression tag
Lys -125-expression tag
Asp -124-expression tag
Asp -123-expression tag
Gly -122-expression tag
Asn -121-expression tag
Tyr -120-expression tag
Lys -119-expression tag
Thr -118-expression tag
Arg -117-expression tag
Ala -116-expression tag
Glu -115-expression tag
Val -114-expression tag
Lys -113-expression tag
Phe -112-expression tag
Glu -111-expression tag
Gly -110-expression tag
Asp -109-expression tag
Thr -108-expression tag
Leu -107-expression tag
Val -106-expression tag
Asn -105-expression tag
Arg -104-expression tag
Ile -103-expression tag
Glu -102-expression tag
Leu -101-expression tag
Lys -100-expression tag
Gly -99-expression tag
Ile -98-expression tag
Asp -97-expression tag
Phe -96-expression tag
Lys -95-expression tag
Glu -94-expression tag
Asp -93-expression tag
Gly -92-expression tag
Asn -91-expression tag
Ile -90-expression tag
Leu -89-expression tag
Gly -88-expression tag
His -87-expression tag
Lys -86-expression tag
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Glu -84-expression tag
Tyr -83-expression tag
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Tyr -81-expression tag
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His -78-expression tag
Asn -77-expression tag
Val -76-expression tag
Tyr -75-expression tag
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Ala -72-expression tag
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Lys -70-expression tag
Gln -69-expression tag
Lys -68-expression tag
Asn -67-expression tag
Gly -66-expression tag
Ile -65-expression tag
Lys -64-expression tag
Val -63-expression tag
Asn -62-expression tag
Phe -61-expression tag
Lys -60-expression tag
Ile -59-expression tag
Arg -58-expression tag
His -57-expression tag
Asn -56-expression tag
Ile -55-expression tag
Glu -54-expression tag
Asp -53-expression tag
Gly -52-expression tag
Ser -51-expression tag
Val -50-expression tag
Gln -49-expression tag
Leu -48-expression tag
Ala -47-expression tag
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His -45-expression tag
Tyr -44-expression tag
Gln -43-expression tag
Gln -42-expression tag
Asn -41-expression tag
Thr -40-expression tag
Pro -39-expression tag
Ile -38-expression tag
Gly -37-expression tag
Asp -36-expression tag
Gly -35-expression tag
Pro -34-expression tag
Val -33-expression tag
Leu -32-expression tag
Leu -31-expression tag
Pro -30-expression tag
Asp -29-expression tag
Asn -28-expression tag
His -27-expression tag
Tyr -26-expression tag
Leu -25-expression tag
Ser -24-expression tag
Thr -23-expression tag
Gln -22-expression tag
Ser -21-expression tag
Ala -20-expression tag
Leu -19-expression tag
Ser -18-expression tag
Lys -17-expression tag
Asp -16-expression tag
Pro -15-expression tag
Asn -14-expression tag
Glu -13-expression tag
Lys -12-expression tag
Arg -11-expression tag
Asp -10-expression tag
His -9-expression tag
Met -8-expression tag
Val -7-expression tag
Leu -6-expression tag
Leu -5-expression tag
Glu -4-expression tag
Phe -3-expression tag
Val -2-expression tag
Thr -1-expression tag
Ala 0-expression tag
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Ile 3-expression tag
Thr 4-expression tag
Leu 5-expression tag
Gly 6-expression tag
Met 7-expression tag
Asp 8-expression tag
Glu 9-expression tag
Leu 10-expression tag
Tyr 11-expression tag
Lys 12-expression tag
Leu 13-expression tag
Glu 14-expression tag
Val 15-expression tag
Leu 16-expression tag
Phe 17-expression tag
Gln 18-expression tag
Gly 19-expression tag
Pro 20-expression tag
Gly 21-expression tag
Ser 22-expression tag
Gly 440-expression tag
Gly 441-expression tag
Gly 442-expression tag
Gly 443-expression tag
Ser 444-expression tag
Thr 445-expression tag
Thr 446-expression tag
Ala 447-expression tag
Pro 448-expression tag
Ser 449-expression tag
Ala 450-expression tag
Gln 451-expression tag
Leu 452-expression tag
Glu 453-expression tag
Lys 454-expression tag
Glu 455-expression tag
Leu 456-expression tag
Gln 457-expression tag
Ala 458-expression tag
Leu 459-expression tag
Glu 460-expression tag
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Glu 462-expression tag
Asn 463-expression tag
Ala 464-expression tag
Gln 465-expression tag
Leu 466-expression tag
Glu 467-expression tag
Trp 468-expression tag
Glu 469-expression tag
Leu 470-expression tag
Gln 471-expression tag
Ala 472-expression tag
Leu 473-expression tag
Glu 474-expression tag
Lys 475-expression tag
Glu 476-expression tag
Leu 477-expression tag
Ala 478-expression tag
Gln 479-expression tag
C, D: 21 - 135 (UniProt: P05113)
PDBExternal DatabaseDetails
Asp 13-expression tag
Tyr 14-expression tag
Lys 15-expression tag
Asp 16-expression tag
Asp 17-expression tag
Asp 18-expression tag
Asp 19-expression tag
Lys 20-expression tag
Gly 136-expression tag
Ala 137-expression tag
Ala 138-expression tag
Glu 139-expression tag
Asp 140-expression tag
Gln 141-expression tag
Val 142-expression tag
Asp 143-expression tag
Pro 144-expression tag
Arg 145-expression tag
Leu 146-expression tag
Ile 147-expression tag
Asp 148-expression tag
Gly 149-expression tag
Lys 150-expression tag
His 151-expression tag
His 152-expression tag
His 153-expression tag
His 154-expression tag
His 155-expression tag
His 156-expression tag
His 157-expression tag
His 158-expression tag
F: 21 - 341 (UniProt: Q01344)
PDBExternal DatabaseDetails
Asp 13-expression tag
Tyr 14-expression tag
Lys 15-expression tag
Asp 16-expression tag
Asp 17-expression tag
Asp 18-expression tag
Asp 19-expression tag
Lys 20-expression tag
Gly 342-expression tag
Gly 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Ser 346-expression tag
Thr 347-expression tag
Thr 348-expression tag
Ala 349-expression tag
Pro 350-expression tag
Ser 351-expression tag
Ala 352-expression tag
Gln 353-expression tag
Leu 354-expression tag
Lys 355-expression tag
Lys 356-expression tag
Lys 357-expression tag
Leu 358-expression tag
Gln 359-expression tag
Ala 360-expression tag
Leu 361-expression tag
Lys 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Asn 365-expression tag
Ala 366-expression tag
Gln 367-expression tag
Leu 368-expression tag
Lys 369-expression tag
Trp 370-expression tag
Lys 371-expression tag
Leu 372-expression tag
Gln 373-expression tag
Ala 374-expression tag
Leu 375-expression tag
Lys 376-expression tag
Lys 377-expression tag
Lys 378-expression tag
Leu 379-expression tag
Ala 380-expression tag
Gln 381-expression tag
Gly 382-expression tag
Ala 383-expression tag
Ala 384-expression tag
Glu 385-expression tag
Asp 386-expression tag
Gln 387-expression tag
Val 388-expression tag
Asp 389-expression tag
Pro 390-expression tag
Arg 391-expression tag
Leu 392-expression tag
Ile 393-expression tag
Asp 394-expression tag
Gly 395-expression tag
Lys 396-expression tag
His 397-expression tag
His 398-expression tag
His 399-expression tag
His 400-expression tag
His 401-expression tag
His 402-expression tag
His 403-expression tag
His 404-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight240419.8
Non-Polymers*Number of molecules5
Total formula weight1106.0
All*Total formula weight241525.8
*Water molecules are not included.

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PDB entries from 2024-05-15

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