8TLD

Structure of the IL-5 Signaling Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0002639	biological_process	positive regulation of immunoglobulin production
C	0005125	molecular_function	cytokine activity
C	0005137	molecular_function	interleukin-5 receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006954	biological_process	inflammatory response
C	0008083	molecular_function	growth factor activity
C	0008284	biological_process	positive regulation of cell population proliferation
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0030890	biological_process	positive regulation of B cell proliferation
C	0038043	biological_process	interleukin-5-mediated signaling pathway
C	0045645	biological_process	positive regulation of eosinophil differentiation
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
C	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
C	0071803	biological_process	positive regulation of podosome assembly
D	0002639	biological_process	positive regulation of immunoglobulin production
D	0005125	molecular_function	cytokine activity
D	0005137	molecular_function	interleukin-5 receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006954	biological_process	inflammatory response
D	0008083	molecular_function	growth factor activity
D	0008284	biological_process	positive regulation of cell population proliferation
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0030890	biological_process	positive regulation of B cell proliferation
D	0038043	biological_process	interleukin-5-mediated signaling pathway
D	0045645	biological_process	positive regulation of eosinophil differentiation
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
D	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
D	0071803	biological_process	positive regulation of podosome assembly

Functional Information from PROSITE/UniProt

site_id	PS01355
Number of Residues	33
Details	HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. LepstrywarVRvrtsrtgyngi.........WSeWSearsW

Chain	Residue	Details
B	LEU399-TRP431

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site_id	PS01356
Number of Residues	30
Details	HEMATOPO_REC_S_F2 Short hematopoietin receptor family 2 signature. LhCtWlvGtdapeDtqYfLyyrygswtee....C

Chain	Residue	Details
F	LEU153-CYS182

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
F	ASN35
F	ASN131
F	ASN216
F	ASN244

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:2361960

Chain	Residue	Details
C	THR23
D	THR23

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:2361960

Chain	Residue	Details
C	ASN48
D	ASN48

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