8TLD

Structure of the IL-5 Signaling Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004896	molecular_function	cytokine receptor activity
B	0006091	biological_process	generation of precursor metabolites and energy
B	0008218	biological_process	bioluminescence
B	0016020	cellular_component	membrane
C	0002639	biological_process	positive regulation of immunoglobulin production
C	0005125	molecular_function	cytokine activity
C	0005137	molecular_function	interleukin-5 receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0006954	biological_process	inflammatory response
C	0006955	biological_process	immune response
C	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
C	0008083	molecular_function	growth factor activity
C	0008284	biological_process	positive regulation of cell population proliferation
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0030890	biological_process	positive regulation of B cell proliferation
C	0038043	biological_process	interleukin-5-mediated signaling pathway
C	0045645	biological_process	positive regulation of eosinophil differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
C	0071803	biological_process	positive regulation of podosome assembly
D	0002639	biological_process	positive regulation of immunoglobulin production
D	0005125	molecular_function	cytokine activity
D	0005137	molecular_function	interleukin-5 receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005886	cellular_component	plasma membrane
D	0006954	biological_process	inflammatory response
D	0006955	biological_process	immune response
D	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
D	0008083	molecular_function	growth factor activity
D	0008284	biological_process	positive regulation of cell population proliferation
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0030890	biological_process	positive regulation of B cell proliferation
D	0038043	biological_process	interleukin-5-mediated signaling pathway
D	0045645	biological_process	positive regulation of eosinophil differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
D	0071803	biological_process	positive regulation of podosome assembly
E	0004896	molecular_function	cytokine receptor activity
E	0006091	biological_process	generation of precursor metabolites and energy
E	0008218	biological_process	bioluminescence
E	0016020	cellular_component	membrane
F	0004896	molecular_function	cytokine receptor activity
F	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS01355
Number of Residues	33
Details	HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. LepstrywarVRvrtsrtgyngi.........WSeWSearsW

Chain	Residue	Details
B	LEU399-TRP431

---

site_id	PS01356
Number of Residues	30
Details	HEMATOPO_REC_S_F2 Short hematopoietin receptor family 2 signature. LhCtWlvGtdapeDtqYfLyyrygswtee....C

Chain	Residue	Details
F	LEU153-CYS182

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16754968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18692472","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	190
Details	Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"2361960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"2361960","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	91
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---