8TJA

CRYSTAL STRUCTURE OF THE A/Ecuador/1374/2016(H3N2) INFLUENZA VIRUS HEMAGGLUTININ WITH HUMAN RECEPTOR ANALOG 6'-SLNLN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Hemagglutinin HA1 chain	polymer	323	35788.3	1	UniProt (A0A4P8J8E1) Pfam (PF00509)	Influenza A virus
2	B (B)	Hemagglutinin HA2 chain	polymer	174	19996.2	1	UniProt (A0A3G1NFN9) Pfam (PF00509)	Influenza A virus
3	C (C)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
4	D (D)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
5	E (E)	N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1039.9	1	In PDB GlyTouCan (G60430KO)
6	F, G, H, I (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
7	J, O (A, B)	TETRAETHYLENE GLYCOL	non-polymer		194.2	2	Chemie (PG4)
8	K, L, M, P, Q... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	9	Chemie (EDO)
9	N, V, W, X (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	4	Chemie (PEG)
10	Y, Z (B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
11	AA, BA (A, B)	water	water		18.0	451	Chemie (HOH)

Sequence modifications

A: 11 - 329 (UniProt: A0A4P8J8E1)

PDB	External Database	Details
Ala 7	-	expression tag
Asp 8	-	expression tag
Pro 9	-	expression tag
Gly 10	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	55784.6
Branched	Number of molecules	3
	Total formula weight	2537.3
Non-Polymers*	Number of molecules	21
	Total formula weight	2448.5
All*	Total formula weight	60770.4

*Water molecules are not included.