8THU
Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (G, C) | Histone H2A.Z | polymer | 128 | 13581.8 | 2 | UniProt (P0C0S5) Pfam (PF00125) Pfam (PF16211) | Homo sapiens (human) | H2A/z |
| 2 | C, F (A, E) | Histone H3.2 | polymer | 135 | 15303.9 | 2 | UniProt (P84233) Pfam (PF00125) | Xenopus laevis (African clawed frog) | Histone H3 |
| 3 | D, G (B, F) | Histone H4 | polymer | 103 | 11394.4 | 2 | UniProt (A0A8J1LTD2) Pfam (PF15511) UniProt (by SIFTS) (P62799) | Xenopus laevis (African clawed frog) | |
| 4 | E, H (D, H) | Histone H2B 1.1 | polymer | 123 | 13655.9 | 2 | UniProt (P02281) Pfam (PF00125) | Xenopus laevis (African clawed frog) | H2B1.1 |
| 5 | I (I) | DNA (145-MER) | polymer | 146 | 44824.6 | 1 | synthetic construct | ||
| 6 | J (J) | DNA (146-MER) | polymer | 146 | 45304.9 | 1 | synthetic construct |
Sequence modifications
A, E: 1 - 135 (UniProt: P84233)
D, H: 4 - 125 (UniProt: P02281)
| PDB | External Database | Details |
|---|---|---|
| Ala 102 | Gly 103 | variant |
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | initiating methionine |
| Thr 32 | Ser 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 198001.6 | |
| All* | Total formula weight | 198001.6 |
