8TF5
Crystal structure of orphan G protein-coupled receptor 6, pseudoapo form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | G-protein coupled receptor 6,Soluble cytochrome b562 chimera,Soluble cytochrome b562,G-protein coupled receptor 6 | polymer | 436 | 47664.3 | 1 | UniProt (P46095) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) | Homo sapiens (human) | Cytochrome b-562 |
| 2 | B, C, L, M, O (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 5 | Chemie (OLC) | |||
| 3 | D, F (A) | 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL | non-polymer | 296.4 | 2 | Chemie (P15) | |||
| 4 | E, G, H, I, J... (A) | OLEIC ACID | non-polymer | 282.5 | 12 | Chemie (OLA) | |||
| 5 | U (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 6 | V (A) | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
A: 48 - 256 (UniProt: P46095)
A: 1001 - 1106 (UniProt: P0ABE7)
A: 270 - 362 (UniProt: P46095)
| PDB | External Database | Details |
|---|---|---|
| Met 32 | - | initiating methionine |
| Lys 33 | - | expression tag |
| Thr 34 | - | expression tag |
| Ile 35 | - | expression tag |
| Ile 36 | - | expression tag |
| Ala 37 | - | expression tag |
| Leu 38 | - | expression tag |
| Ser 39 | - | expression tag |
| Tyr 40 | - | expression tag |
| Ile 41 | - | expression tag |
| Phe 42 | - | expression tag |
| Cys 43 | - | expression tag |
| Leu 44 | - | expression tag |
| Val 45 | - | expression tag |
| Phe 46 | - | expression tag |
| Ala 47 | - | expression tag |
| Leu 123 | Cys 123 | engineered mutation |
| Pro 173 | Ala 173 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | engineered mutation |
| Ala 900 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Arg 279 | Gly 279 | engineered mutation |
| Cys 291 | Ser 291 | engineered mutation |
| Leu 320 | Tyr 320 | engineered mutation |
| Asp 345 | Cys 345 | engineered mutation |
| Glu 363 | - | expression tag |
| Phe 364 | - | expression tag |
| His 365 | - | expression tag |
| His 366 | - | expression tag |
| His 367 | - | expression tag |
| His 368 | - | expression tag |
| His 369 | - | expression tag |
| His 370 | - | expression tag |
| His 371 | - | expression tag |
| His 372 | - | expression tag |
| His 373 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 47664.3 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 6151.6 | |
| All* | Total formula weight | 53815.9 |
