8TE4
Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, E, H... | DNA (cytosine-5)-methyltransferase 3A | polymer | 287 | 32797.8 | 8 | UniProt (Q9Y6K1) Pfam (PF00145) In PDB | Homo sapiens (human) | Dnmt3a,Cysteine methyltransferase DNMT3A,DNA methyltransferase HsaIIIA,DNA MTase HsaIIIA,M.HsaIIIA |
| 2 | A, B, C, D | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) | |||
| 3 | D, A, B, C | GLYCEROL | non-polymer | 92.1 | 16 | Chemie (GOL) | |||
| 4 | water | water | 18.0 | 608 | Chemie (HOH) |
Sequence modifications
A, B, C, E, H, F, D, G: 628 - 912 (UniProt: Q9Y6K1)
| PDB | External Database | Details |
|---|---|---|
| Gly 626 | - | expression tag |
| Ser 627 | - | expression tag |
| Ala 879 | Asn 879 | engineered mutation |
| His 882 | Arg 882 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 262382.2 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 3011.1 | |
| All* | Total formula weight | 265393.3 |
