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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8TAR

APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Anaphase-promoting complex subunit 1polymer1944217566.11UniProt (Q9H1A4)
Pfam (PF12859)
Pfam (PF20518)
Pfam (PF21282)
Pfam (PF18122)		Homo sapiens (human)
2B
(B)		G2/mitotic-specific cyclin-B1polymer121284.51UniProt (P14635)Homo sapiens (human)
3C
(C)		Anaphase-promoting complex subunit 11polymer849854.61UniProt (Q9NYG5)
Pfam (PF12861)		Homo sapiens (human)APC11,Cyclosome subunit 11,Hepatocellular carcinoma-associated RING finger protein
4D
(D)		Anaphase-promoting complex subunit 15polymer566556.31UniProt (P60006)
Pfam (PF15243)		Homo sapiens (human)
5E, T
(G, W)		Anaphase-promoting complex subunit CDC26polymer859920.12UniProt (Q8NHZ8)
Pfam (PF10471)		Homo sapiens (human)Anaphase-promoting complex subunit 12,APC12,Cell division cycle protein 26 homolog
6F
(H)		Anaphase-promoting complex subunit 16polymer586764.71UniProt (Q96DE5)
Pfam (PF17256)		Homo sapiens (human)APC16,Cyclosome subunit 16
7G
(I)		Anaphase-promoting complex subunit 4polymer80892303.31UniProt (Q9UJX5)
Pfam (PF12894)
Pfam (PF12896)		Homo sapiens (human)APC4,Cyclosome subunit 4
8H, N
(J, P)		Cell division cycle protein 27 homologpolymer82492519.52UniProt (P30260)
Pfam (PF12895)
Pfam (PF00515)		Homo sapiens (human)Anaphase-promoting complex subunit 3,APC3,CDC27 homolog,CDC27Hs,H-NUC
9I, Q
(K, S)		Cell division cycle protein 16 homologpolymer62071929.72UniProt (Q13042)
Pfam (PF12895)
Pfam (PF13424)		Homo sapiens (human)Anaphase-promoting complex subunit 6,APC6,CDC16 homolog,CDC16Hs,Cyclosome subunit 6
10J
(L)		Anaphase-promoting complex subunit 10polymer18521310.21UniProt (Q9UM13)
Pfam (PF03256)		Homo sapiens (human)APC10,Cyclosome subunit 10
11K
(M)		Anaphase-promoting complex subunit 13polymer748528.31UniProt (Q9BS18)
Pfam (PF05839)		Homo sapiens (human)APC13,Cyclosome subunit 13
12L
(N)		Anaphase-promoting complex subunit 2polymer82294149.21UniProt (Q9UJX6)
Pfam (PF00888)
Pfam (PF08672)		Homo sapiens (human)APC2,Cyclosome subunit 2
13M
(O)		Anaphase-promoting complex subunit 5polymer75585446.01UniProt (Q9UJX4)
Pfam (PF21371)
Pfam (PF12862)		Homo sapiens (human)APC5,Cyclosome subunit 5
14O
(Q)		Ubiquitin-conjugating enzyme E2 Cpolymer14516346.61UniProt (O00762)
Pfam (PF00179)		Homo sapiens (human)
15P
(R)		Fizzy-related protein homologpolymer49655253.21UniProt (Q9UM11)
Pfam (PF12894)
Pfam (PF00400)		Homo sapiens (human)
16R, S
(U, V)		Cell division cycle protein 23 homologpolymer59769075.12UniProt (Q9UJX2)
Pfam (PF04049)		Homo sapiens (human)Anaphase-promoting complex subunit 8,APC8,Cyclosome subunit 8
17U, V
(Y, Z)		Anaphase-promoting complex subunit 7polymer56563204.02UniProt (Q9UJX3)
Pfam (PF13181)
Pfam (PF13432)		Homo sapiens (human)APC7,Cyclosome subunit 7
18W, X, Y, Z
(C, N)		ZINC IONnon-polymer65.44Chemie (ZN)
Sequence modifications
A: 1 - 1944 (UniProt: Q9H1A4)
PDBExternal DatabaseDetails
Glu 202Ser 202engineered mutation
Glu 286Ser 286engineered mutation
Glu 291Thr 291engineered mutation
Glu 313Ser 313engineered mutation
Glu 316Thr 316engineered mutation
Glu 317Ser 317engineered mutation
Glu 334Ser 334engineered mutation
Glu 341Ser 341engineered mutation
Glu 343Ser 343engineered mutation
Glu 355Ser 355engineered mutation
Glu 362Ser 362engineered mutation
Glu 372Ser 372engineered mutation
Glu 377Ser 377engineered mutation
Glu 537Thr 537engineered mutation
Glu 547Ser 547engineered mutation
Glu 555Ser 555engineered mutation
Glu 569Ser 569engineered mutation
Glu 688Ser 688engineered mutation
Glu 699Ser 699engineered mutation
Glu 916Ser 916engineered mutation
Glu 1347Ser 1347engineered mutation
G, W: 1 - 85 (UniProt: Q8NHZ8)
PDBExternal DatabaseDetails
Glu 51Ser 51engineered mutation
Glu 52Ser 52engineered mutation
Glu 82Ser 82engineered mutation
I: 1 - 808 (UniProt: Q9UJX5)
PDBExternal DatabaseDetails
Glu 777Ser 777engineered mutation
Glu 779Ser 779engineered mutation
J, P: 1 - 824 (UniProt: P30260)
PDBExternal DatabaseDetails
Glu 200Thr 200engineered mutation
Glu 205Thr 205engineered mutation
Glu 220Ser 220engineered mutation
Glu 241Ser 241engineered mutation
Glu 276Ser 276engineered mutation
Glu 320Ser 320engineered mutation
Glu 336Ser 336engineered mutation
Glu 339Ser 339engineered mutation
Glu 386Ser 386engineered mutation
Glu 387Ser 387engineered mutation
Glu 393Ser 393engineered mutation
Glu 426Ser 426engineered mutation
Glu 435Ser 435engineered mutation
Glu 446Thr 446engineered mutation
K, S: 1 - 620 (UniProt: Q13042)
PDBExternal DatabaseDetails
Glu 112Ser 112engineered mutation
Glu 560Ser 560engineered mutation
Glu 581Thr 581engineered mutation
Glu 585Thr 585engineered mutation
Glu 586Ser 586engineered mutation
L: 1 - 185 (UniProt: Q9UM13)
PDBExternal DatabaseDetails
Glu 3Thr 3engineered mutation
N: 1 - 822 (UniProt: Q9UJX6)
PDBExternal DatabaseDetails
Glu 218Ser 218engineered mutation
Glu 314Ser 314engineered mutation
Glu 470Ser 470engineered mutation
Glu 534Ser 534engineered mutation
Glu 811Ser 811engineered mutation
O: 1 - 755 (UniProt: Q9UJX4)
PDBExternal DatabaseDetails
Glu 178Thr 178engineered mutation
Glu 179Ser 179engineered mutation
Glu 195Ser 195engineered mutation
Glu 202Ser 202engineered mutation
Glu 221Ser 221engineered mutation
Glu 232Thr 232engineered mutation
Glu 364Ser 364engineered mutation
U, V: 1 - 597 (UniProt: Q9UJX2)
PDBExternal DatabaseDetails
Glu 542Thr 542engineered mutation
Glu 562Thr 562engineered mutation
Glu 582Thr 582engineered mutation
Glu 588Ser 588engineered mutation
Glu 596Thr 596engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains22
Total formula weight1228659.9
Non-Polymers*Number of molecules4
Total formula weight261.6
All*Total formula weight1228921.5
*Water molecules are not included.

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PDB entries from 2025-06-11

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