8TAO
Quis and CDPPB bound active mGlu5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Metabotropic glutamate receptor 5 | polymer | 881 | 98868.3 | 2 | UniProt (P41594) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) In PDB | Homo sapiens (human) | mGluR5 |
| 2 | C, D | Nb43 | polymer | 123 | 13354.7 | 2 | Lama glama | ||
| 3 | A, B | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID | non-polymer | 189.1 | 2 | Chemie (QUS) | |||
| 4 | B | 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide | non-polymer | 364.4 | 1 | Chemie (YKU) |
Sequence modifications
A, B: 20 - 876 (UniProt: P41594)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Lys -3 | - | expression tag |
| Thr -2 | - | expression tag |
| Ile -1 | - | expression tag |
| Ile 0 | - | expression tag |
| Ala 1 | - | expression tag |
| Leu 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Tyr 4 | - | expression tag |
| Ile 5 | - | expression tag |
| Phe 6 | - | expression tag |
| Cys 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Val 9 | - | expression tag |
| Phe 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Asp 12 | - | expression tag |
| Tyr 13 | - | expression tag |
| Lys 14 | - | expression tag |
| Asp 15 | - | expression tag |
| Asp 16 | - | expression tag |
| Asp 17 | - | expression tag |
| Asp 18 | - | expression tag |
| Ala 19 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 224445.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 742.7 | |
| All* | Total formula weight | 225188.6 |
