8T70
Cryptococcus neoformans protein farnesyltransferase in complex with FPTII and TKCMIIM peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | polymer | 349 | 40913.2 | 1 | UniProt (J9VSJ6) | Cryptococcus neoformans | |
| 2 | B (B) | Protein farnesyltransferase subunit beta | polymer | 520 | 56806.9 | 1 | UniProt (T2BPA1) | Cryptococcus neoformans | |
| 3 | C (P) | MET-ILE-ILE-MET | polymer | 7 | 840.1 | 1 | synthetic construct | ||
| 4 | AA, BA, CA, D, DA... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 23 | Chemie (EDO) | |||
| 5 | L (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | M, N, O (B) | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid | non-polymer | 237.3 | 3 | Chemie (3FX) | |||
| 7 | P (B) | [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID | non-polymer | 359.4 | 1 | Chemie (FII) | |||
| 8 | Q (B) | benzenethiol | non-polymer | 110.2 | 1 | Chemie (BT6) | |||
| 9 | GA, HA, IA (A, B, P) | water | water | 18.0 | 372 | Chemie (HOH) |
Sequence modifications
A: 1 - 335 (UniProt: J9VSJ6)
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Ser -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Leu 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 98560.3 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 2674.5 | |
| All* | Total formula weight | 101234.8 |
