8T52

HIV-1 Integrase Catalytic Core Domain (CCD) F185H/Y99H/A128T Mutant Complexed with EKC-110

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Integrase	polymer	172	18901.6	1	UniProt (F2WR52) In PDB	Human immunodeficiency virus 1
2	A	(2S)-tert-butoxy{4-(4-chlorophenyl)-2,6-dimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid	non-polymer		481.0	1	Chemie (QD6)
3		water	water		18.0	44	Chemie (HOH)

Sequence modifications

A: 41 - 212 (UniProt: F2WR52)

PDB	External Database	Details
His 99	Tyr 99	engineered mutation
Thr 128	Ala 128	engineered mutation
His 185	Phe 185	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	18901.6
Non-Polymers*	Number of molecules	1
	Total formula weight	481.0
All*	Total formula weight	19382.6

*Water molecules are not included.