8T1I
Atomic model of the mammalian Mediator complex with MED26 subunit
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mediator of RNA polymerase II transcription subunit 1 | polymer | 1575 | 167354.9 | 1 | UniProt (Q925J9) Pfam (PF10744) | Mus musculus (house mouse) | Mediator complex subunit 1,Peroxisome proliferator-activated receptor-binding protein,PBP,PPAR-binding protein,Thyroid hormone receptor-associated protein complex 220 kDa component,Trap220,Thyroid receptor-interacting protein 2,TR-interacting protein 2,TRIP-2 |
| 2 | B (B) | Mediator of RNA polymerase II transcription subunit 4 | polymer | 270 | 29817.5 | 1 | UniProt (Q9CQA5) Pfam (PF10018) | Mus musculus (house mouse) | Mediator complex subunit 4 |
| 3 | C (C) | Mediator of RNA polymerase II transcription subunit 6 | polymer | 246 | 28473.6 | 1 | UniProt (Q921D4) Pfam (PF04934) | Mus musculus (house mouse) | Mediator complex subunit 6 |
| 4 | D (D) | Mediator of RNA polymerase II transcription subunit 7 | polymer | 233 | 27244.3 | 1 | UniProt (Q9CZB6) Pfam (PF05983) | Mus musculus (house mouse) | Cofactor required for Sp1 transcriptional activation subunit 9,CRSP complex subunit 9,Mediator complex subunit 7 |
| 5 | E (E) | Mediator of RNA polymerase II transcription subunit 8 | polymer | 268 | 29232.0 | 1 | UniProt (Q9D7W5) Pfam (PF10232) | Mus musculus (house mouse) | Activator-recruited cofactor 32 kDa component,ARC32,Mediator complex subunit 8 |
| 6 | F (F) | Mediator of RNA polymerase II transcription subunit 9 | polymer | 142 | 15729.1 | 1 | UniProt (Q8VCS6) Pfam (PF07544) | Mus musculus (house mouse) | Mediator complex subunit 9 |
| 7 | G (G) | Mediator of RNA polymerase II transcription subunit 10 | polymer | 135 | 15683.9 | 1 | UniProt (Q9CXU0) Pfam (PF09748) | Mus musculus (house mouse) | Mediator complex subunit 10 |
| 8 | H (H) | Mediator of RNA polymerase II transcription subunit 11 | polymer | 117 | 13147.8 | 1 | UniProt (Q9D8C6) Pfam (PF10280) | Mus musculus (house mouse) | Mediator complex subunit 11 |
| 9 | I (I) | Mediator of RNA polymerase II transcription subunit 14 | polymer | 1459 | 161144.8 | 1 | UniProt (A2ABV5) Pfam (PF22981) Pfam (PF25065) Pfam (PF25067) Pfam (PF22984) Pfam (PF22983) Pfam (PF25069) Pfam (PF08638) | Mus musculus (house mouse) | Cofactor required for Sp1 transcriptional activation subunit 2,CRSP complex subunit 2,Mediator complex subunit 14,Thyroid hormone receptor-associated protein complex 170 kDa component,Trap170 |
| 10 | J (J) | Mediator of RNA polymerase II transcription subunit 15 | polymer | 789 | 86682.9 | 1 | UniProt (Q924H2) Pfam (PF09606) Pfam (PF21538) Pfam (PF21539) | Mus musculus (house mouse) | Mediator complex subunit 15,Positive cofactor 2 glutamine/Q-rich-associated protein,PC2 glutamine/Q-rich-associated protein,mPcqap |
| 11 | K (K) | Mediator of RNA polymerase II transcription subunit 16 | polymer | 828 | 91890.5 | 1 | UniProt (Q6PGF3) Pfam (PF00400) Pfam (PF11635) Pfam (PF20718) Pfam (PF20719) | Mus musculus (house mouse) | Mediator complex subunit 16,Thyroid hormone receptor-associated protein 5,Thyroid hormone receptor-associated protein complex 95 kDa component,Trap95,Vitamin D3 receptor-interacting protein complex 92 kDa component,DRIP92 |
| 12 | L (L) | Mediator of RNA polymerase II transcription subunit 17 | polymer | 649 | 72555.6 | 1 | UniProt (Q8VCD5) Pfam (PF10156) | Mus musculus (house mouse) | Cofactor required for Sp1 transcriptional activation subunit 6,CRSP complex subunit 6,Mediator complex subunit 17,Thyroid hormone receptor-associated protein complex 80 kDa component |
| 13 | M (M) | Mediator of RNA polymerase II transcription subunit 18 | polymer | 208 | 23675.7 | 1 | UniProt (Q9CZ82) Pfam (PF09637) | Mus musculus (house mouse) | Mediator complex subunit 18 |
| 14 | N (N) | Mediator of RNA polymerase II transcription subunit 19 | polymer | 240 | 25866.5 | 1 | UniProt (Q8C1S0) Pfam (PF10278) | Mus musculus (house mouse) | Mediator complex subunit 19 |
| 15 | O (O) | Mediator of RNA polymerase II transcription subunit 20 | polymer | 212 | 23213.8 | 1 | UniProt (Q9R0X0) Pfam (PF08612) | Mus musculus (house mouse) | Mediator complex subunit 20,TRF-proximal protein homolog |
| 16 | P (P) | Mediator of RNA polymerase II transcription subunit 21 | polymer | 144 | 15600.3 | 1 | UniProt (Q9CQ39) Pfam (PF11221) | Mus musculus (house mouse) | Mediator complex subunit 21,RNA polymerase II holoenzyme component SRB7,RNAPII complex component SRB7 |
| 17 | Q (Q) | Mediator of RNA polymerase II transcription subunit 22 | polymer | 200 | 22304.8 | 1 | UniProt (Q62276) Pfam (PF06179) | Mus musculus (house mouse) | Mediator complex subunit 22,Surfeit locus protein 5,Surf-5 |
| 18 | R (R) | Mediator of RNA polymerase II transcription subunit 23 | polymer | 1367 | 156265.7 | 1 | UniProt (Q80YQ2) Pfam (PF11573) | Mus musculus (house mouse) | Cofactor required for Sp1 transcriptional activation subunit 3,CRSP complex subunit 3,Mediator complex subunit 23,Protein sur-2 homolog,mSur-2 |
| 19 | S (S) | Mediator of RNA polymerase II transcription subunit 24 | polymer | 987 | 110106.9 | 1 | UniProt (Q99K74) Pfam (PF11277) | Mus musculus (house mouse) | Mediator complex subunit 24,Thyroid hormone receptor-associated protein 4,Thyroid hormone receptor-associated protein complex 100 kDa component,Trap100,mTRAP100 |
| 20 | T (T) | Mediator of RNA polymerase II transcription subunit 25 | polymer | 745 | 78173.3 | 1 | UniProt (Q8VCB2) Pfam (PF11265) Pfam (PF11235) Pfam (PF11232) | Mus musculus (house mouse) | Mediator complex subunit 25,mMED25 |
| 21 | U (U) | Mediator of RNA polymerase II transcription subunit 26 | polymer | 588 | 64773.5 | 1 | UniProt (Q7TN02) Pfam (PF08711) Pfam (PF15694) Pfam (PF15693) | Mus musculus (house mouse) | Cofactor required for Sp1 transcriptional activation subunit 7,CRSP complex subunit 7,Mediator complex subunit 26 |
| 22 | V (V) | Mediator of RNA polymerase II transcription subunit 27 | polymer | 311 | 35343.6 | 1 | UniProt (Q9DB40) Pfam (PF11571) | Mus musculus (house mouse) | Cofactor required for Sp1 transcriptional activation subunit 8,CRSP complex subunit 8,Mediator complex subunit 27 |
| 23 | W (W) | Mediator of RNA polymerase II transcription subunit 28 | polymer | 178 | 19558.1 | 1 | UniProt (Q920D3) Pfam (PF11594) | Mus musculus (house mouse) | Mediator complex subunit 28 |
| 24 | X (X) | Mediator of RNA polymerase II transcription subunit 29 | polymer | 199 | 21027.7 | 1 | UniProt (Q9DB91) Pfam (PF11568) | Mus musculus (house mouse) | Intersex-like protein,Mediator complex subunit 29 |
| 25 | Y (Y) | Mediator of RNA polymerase II transcription subunit 30 | polymer | 178 | 20383.4 | 1 | UniProt (Q9CQI9) Pfam (PF11315) | Mus musculus (house mouse) | Mediator complex subunit 30,Thyroid hormone receptor-associated protein 6,Thyroid hormone receptor-associated protein complex 25 kDa component,Trap25 |
| 26 | Z (Z) | Mediator of RNA polymerase II transcription subunit 31 | polymer | 131 | 15792.1 | 1 | UniProt (Q9CXU1) Pfam (PF05669) | Mus musculus (house mouse) | Mediator complex subunit 31,Mediator complex subunit SOH1 |
| 27 | AA (a) | Unknown Peptide | polymer | 20 | 1720.1 | 1 | Mus musculus |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 27 |
| Total formula weight | 1372762.1 | |
| All* | Total formula weight | 1372762.1 |
