8T11
Crystal structure of the PEG10 promoter-bound ONECUT2 R479A/R480A mutant DNA-binding domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | One cut domain family member 2 | polymer | 156 | 18521.5 | 1 | UniProt (O95948) Pfam (PF02376) Pfam (PF00046) | Homo sapiens (human) | Hepatocyte nuclear factor 6-beta,HNF-6-beta,One cut homeobox 2,Transcription factor ONECUT-2,OC-2 |
| 2 | B (B) | DNA (5'-D(P*AP*GP*AP*TP*CP*GP*AP*TP*TP*TP*GP*C)-3') | polymer | 12 | 3677.4 | 1 | Homo sapiens | ||
| 3 | C (C) | DNA (5'-D(P*GP*CP*AP*AP*AP*TP*CP*GP*AP*TP*CP*T)-3') | polymer | 12 | 3646.4 | 1 | Homo sapiens | ||
| 4 | D (A) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 330 - 485 (UniProt: O95948)
| PDB | External Database | Details |
|---|---|---|
| Ala 479 | Arg 479 | engineered mutation |
| Ala 480 | Arg 480 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 25845.3 | |
| All* | Total formula weight | 25845.3 |
