8SUP
Structure of the 48S translation initiation complex assembled on the encephalomyocarditis virus IRES
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (o) | Eukaryotic translation initiation factor 3 subunit A | polymer | 1362 | 164902.7 | 1 | UniProt (G1SMZ5) | Oryctolagus cuniculus (rabbit) | eIF3a,Eukaryotic translation initiation factor 3 subunit 10,eIF-3-theta |
| 2 | B (p) | Eukaryotic translation initiation factor 3 subunit C | polymer | 843 | 97923.5 | 1 | UniProt (A0A5F9CMJ3) | Oryctolagus cuniculus (rabbit) | |
| 3 | C (q) | Eukaryotic translation initiation factor 3 subunit E | polymer | 445 | 52281.6 | 1 | UniProt (G1SUC8) | Oryctolagus cuniculus (rabbit) | |
| 4 | D (r) | Eukaryotic translation initiation factor 3 subunit F | polymer | 364 | 37846.7 | 1 | UniProt (G1SLC2) | Oryctolagus cuniculus (rabbit) | eIF3f,Eukaryotic translation initiation factor 3 subunit 5,eIF-3-epsilon,eIF3 p47 |
| 5 | E (s) | Eukaryotic translation initiation factor 3 subunit H | polymer | 352 | 39952.3 | 1 | UniProt (G1ST95) | Oryctolagus cuniculus (rabbit) | |
| 6 | F (t) | Eukaryotic translation initiation factor 3 subunit K | polymer | 218 | 25129.7 | 1 | UniProt (G1T3L2) | Oryctolagus cuniculus (rabbit) | eIF3k,Eukaryotic translation initiation factor 3 subunit 12,eIF-3 p25 |
| 7 | G (u) | Eukaryotic translation initiation factor 3 subunit L | polymer | 564 | 66804.8 | 1 | UniProt (G1SED9) | Oryctolagus cuniculus (rabbit) | eIF3l,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein |
| 8 | H (v) | Eukaryotic translation initiation factor 3 subunit M | polymer | 374 | 42555.8 | 1 | UniProt (G1SLW8) | Oryctolagus cuniculus (rabbit) | eIF3m |
| 9 | I (2) | 18S rRNA | polymer | 1870 | 603100.9 | 1 | GenBank (2488159015) | Oryctolagus cuniculus (rabbit) | |
| 10 | J (3) | EMCV mRNA | polymer | 89 | 28627.1 | 1 | GenBank (485965777) | Encephalomyocarditis virus | |
| 11 | K (A) | Eukaryotic translation initiation factor 1A, X-chromosomal | polymer | 144 | 16488.4 | 1 | UniProt (P47813) | Homo sapiens (human) | eIF-1A X isoform,Eukaryotic translation initiation factor 4C,eIF-4C |
| 12 | L (B) | uS2 (SA) | polymer | 295 | 32958.0 | 1 | UniProt (G1TLT8) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein SA, 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40 |
| 13 | M (C) | eS1 | polymer | 264 | 30002.1 | 1 | UniProt (G1SS70) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S3a |
| 14 | N (D) | 40S ribosomal protein S2 | polymer | 221 | 24441.8 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 15 | O (E) | uS3 | polymer | 281 | 31146.6 | 1 | UniProt (G1TNM3) | Oryctolagus cuniculus (rabbit) | Ribosomal protein S3 |
| 16 | P (F) | eS4 (S4 X isoform) | polymer | 263 | 29654.9 | 1 | UniProt (G1TK17) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S4 |
| 17 | Q (G) | uS7 | polymer | 204 | 22913.5 | 1 | UniProt (G1TFM5) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S5 |
| 18 | R (H) | eS6 | polymer | 249 | 28751.9 | 1 | UniProt (G1TM55) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S6 |
| 19 | S (I) | eS7 | polymer | 432 | 47356.2 | 1 | UniProt (G1SVB0) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S7 |
| 20 | T (J) | eS8 | polymer | 208 | 24263.4 | 1 | UniProt (G1TJW1) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S8 |
| 21 | U (K) | uS4 | polymer | 194 | 22641.6 | 1 | UniProt (B7NZS8) | Oryctolagus cuniculus (rabbit) | Ribosomal protein S9 |
| 22 | V (L) | eS10 | polymer | 149 | 17156.9 | 1 | UniProt (G1TPV3) | Oryctolagus cuniculus (rabbit) | |
| 23 | W (M) | uS17 | polymer | 158 | 18468.8 | 1 | UniProt (G1TRM4) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S11 |
| 24 | X (N) | eS12 | polymer | 132 | 14539.0 | 1 | UniProt (G1SFR8) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S12 |
| 25 | Y (O) | uS15 | polymer | 151 | 17259.4 | 1 | UniProt (G1SP51) | Oryctolagus cuniculus (rabbit) | Ribosomal protein S13 |
| 26 | Z (P) | Small ribosomal subunit protein uS11 | polymer | 168 | 18134.0 | 1 | UniProt (A0AAA9WYR1) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S14 |
| 27 | AA (Q) | uS19 | polymer | 145 | 17049.2 | 1 | UniProt (G1U0Q2) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S15 |
| 28 | BA (R) | uS9 | polymer | 172 | 19213.5 | 1 | UniProt (G1SGX4) | Oryctolagus cuniculus (rabbit) | Ribosomal protein S16 |
| 29 | CA (S) | eS17 | polymer | 135 | 15552.1 | 1 | UniProt (G1TU13) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S17 |
| 30 | DA (T) | uS13 | polymer | 152 | 17759.8 | 1 | UniProt (G1TPG3) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S18 |
| 31 | EA (U) | eS19 | polymer | 145 | 16235.8 | 1 | UniProt (G1TN62) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S19 |
| 32 | FA (V) | uS10 | polymer | 119 | 13398.8 | 1 | UniProt (G1SIZ2) | Oryctolagus cuniculus (rabbit) | |
| 33 | GA (W) | eS21 | polymer | 83 | 9124.4 | 1 | UniProt (G1TM82) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S21 |
| 34 | HA (X) | uS8 | polymer | 130 | 14865.6 | 1 | UniProt (G1TG89) | Oryctolagus cuniculus (rabbit) | 40S Ribosomal protein S15a |
| 35 | IA (Y) | uS12 | polymer | 143 | 15844.7 | 1 | UniProt (G1SZ47) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S23 |
| 36 | JA (Z) | eS24 | polymer | 131 | 15237.1 | 1 | UniProt (G1T3D8) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S24 |
| 37 | KA (a) | eS25 | polymer | 124 | 13645.0 | 1 | UniProt (G1TDB3) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S25 |
| 38 | LA (b) | eS26 | polymer | 101 | 11645.8 | 1 | UniProt (G1TFE8) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S26 |
| 39 | MA (c) | eS27 | polymer | 84 | 9480.2 | 1 | UniProt (G1TZ76) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S27 |
| 40 | NA (d) | eS28 | polymer | 69 | 7855.1 | 1 | UniProt (G1TIB4) | Oryctolagus cuniculus (rabbit) | 40S Ribosomal protein S28 |
| 41 | OA (e) | uS14 | polymer | 56 | 6690.8 | 1 | UniProt (G1U7M4) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S29 |
| 42 | PA (f) | eS30 | polymer | 133 | 14498.9 | 1 | UniProt (G1T8A2) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S30 |
| 43 | QA (g) | eS31 | polymer | 188 | 21431.7 | 1 | UniProt (G1SK22) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S27a, Ubiquitin carboxyl extension protein 80,Ubiquitin-40S ribosomal protein S27a |
| 44 | RA (h) | Receptor for Activated C Kinase 1 (RACK1) | polymer | 317 | 35115.7 | 1 | UniProt (G1SJB4) | Oryctolagus cuniculus (rabbit) | |
| 45 | SA (i) | Met-tRNAiMet | polymer | 75 | 24231.5 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 46 | TA (j) | Eukaryotic translation initiation factor 2 subunit 1 | polymer | 315 | 36161.2 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 47 | UA (n) | eL41 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) | Oryctolagus cuniculus (rabbit) | 60s ribosomal protein l41 |
| 48 | VA (b) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
p: 71 - 913 (UniProt: A0A5F9CMJ3)
2: 1 - 1869 (GenBank: 2488159015)
3: 518 - 600 (GenBank: 485965777)
B: 1 - 295 (UniProt: G1TLT8)
F: 1 - 263 (UniProt: G1TK17)
J: 1 - 208 (UniProt: G1TJW1)
W: 1 - 83 (UniProt: G1TM82)
b: 2 - 102 (UniProt: G1TFE8)
| PDB | External Database | Details |
|---|---|---|
| Tyr 577 | Ala 556 | conflict |
| PDB | External Database | Details |
|---|---|---|
| U 197 | C 33280513 | conflict |
| C 1095 | U 33279614 | conflict |
| U 1203 | - | insertion |
| G 1205 | A 33279505 | conflict |
| - | G 33279503 | deletion |
| PDB | External Database | Details |
|---|---|---|
| A 831 | - | expression tag |
| A 832 | - | expression tag |
| U 833 | - | expression tag |
| A 834 | - | expression tag |
| U 835 | - | expression tag |
| G 836 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Thr 114 | Ala 114 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | Ser 25 | conflict |
| Arg 51 | Lys 51 | conflict |
| Thr 78 | Ala 78 | conflict |
| Val 156 | Met 156 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Gly 47 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 3 | Ser 3 | conflict |
| Asp 4 | Asn 4 | conflict |
| Gln 33 | Pro 33 | conflict |
| Phe 50 | Ser 50 | conflict |
| Ala 75 | Ser 75 | conflict |
| Asp 76 | His 76 | conflict |
| Lys 81 | Gln 81 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 28 | Cys 28 | conflict |
| Ala 56 | Val 56 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 47 |
| Total formula weight | 1893811.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 1893877.1 |
