8STG
Discovery and clinical validation of RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 2 | polymer | 317 | 36284.8 | 2 | UniProt (P21802) Pfam (PF07714) | Homo sapiens (human) | FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor |
| 2 | C, D (A, B) | N-{4-[(5P)-4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}-2-methylpropanamide | non-polymer | 511.6 | 2 | Chemie (WCJ) |
Sequence modifications
A, B: 458 - 769 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Ser 453 | - | expression tag |
| His 454 | - | expression tag |
| Met 455 | - | expression tag |
| Gly 456 | - | expression tag |
| Ser 457 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72569.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1023.1 | |
| All* | Total formula weight | 73592.7 |
