8STG

Discovery and clinical validation of RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Fibroblast growth factor receptor 2	polymer	317	36284.8	2	UniProt (P21802) Pfam (PF07714) In PDB	Homo sapiens (human)	FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor
2	A, B	N-{4-[(5P)-4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}-2-methylpropanamide	non-polymer		511.6	2	Chemie (WCJ)

Sequence modifications

A, B: 458 - 769 (UniProt: P21802)

PDB	External Database	Details
Ser 453	-	expression tag
His 454	-	expression tag
Met 455	-	expression tag
Gly 456	-	expression tag
Ser 457	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72569.6
Non-Polymers*	Number of molecules	2
	Total formula weight	1023.1
All*	Total formula weight	73592.7

*Water molecules are not included.