8SSO
AurA bound to danusertib and inhibiting monobody Mb2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, D) | Aurora kinase A | polymer | 285 | 32990.8 | 2 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,Breast tumor-amplified kinase,Ipl1- and aurora-related kinase 1,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase Ayk1,Serine/threonine-protein kinase aurora-A |
| 2 | B, D (B, E) | Mb2 | polymer | 93 | 9854.0 | 2 | synthetic construct | ||
| 3 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | F, H (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 5 | G, I (A, D) | N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE | non-polymer | 474.6 | 2 | Chemie (627) | |||
| 6 | J, K, L, M (A, B, D, E) | water | water | 18.0 | 536 | Chemie (HOH) |
Sequence modifications
A, D: 122 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Ser 119 | - | expression tag |
| Val 120 | - | expression tag |
| Asp 121 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 85689.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1129.3 | |
| All* | Total formula weight | 86818.7 |
