8SS9
Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera | polymer | 1026 | 114978.9 | 4 | UniProt (P19491) UniProt (Q8VHW8) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF13903) | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-5 subunit,Transmembrane AMPAR regulatory protein gamma-5,TARP gamma-5 |
| 2 | E, M, S, Z (A, B, C, D) | 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile | non-polymer | 349.4 | 4 | Chemie (6ZP) | |||
| 3 | AA, F, N, T (D, A, B, C) | {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | non-polymer | 409.3 | 4 | Chemie (ZK1) | |||
| 4 | BA, CA, DA, G, H... (D, A, B, C) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 14 | Chemie (PCW) | |||
| 5 | K, Y (A, C) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
| 6 | L, R (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | EA, FA, GA, HA (A, B, C, D) | water | water | 18.0 | 15 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 10 - 826 (UniProt: P19491)
A, B, C, D: 832 - 1035 (UniProt: Q8VHW8)
| PDB | External Database | Details |
|---|---|---|
| Glu 241 | Asn 256 | conflict |
| Leu 382 | Val 397 | conflict |
| - | Leu 399 | deletion |
| - | Thr 400 | deletion |
| - | Glu 401 | deletion |
| - | Leu 402 | deletion |
| - | Pro 403 | deletion |
| - | Ser 404 | deletion |
| Glu 384 | Gly 405 | conflict |
| Asp 385 | Asn 406 | conflict |
| Gln 392 | Asn 413 | conflict |
| Gly 827 | - | linker |
| Thr 828 | - | linker |
| Gly 829 | - | linker |
| Ser 830 | - | linker |
| Ala 831 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 459915.4 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 14873.5 | |
| All* | Total formula weight | 474789.0 |
