8SS9

Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera	polymer	1026	114978.9	4	UniProt (P19491) UniProt (Q8VHW8) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF13903) In PDB	Rattus norvegicus (Norway rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-5 subunit,Transmembrane AMPAR regulatory protein gamma-5,TARP gamma-5
2	A, B, C, D	2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile	non-polymer		349.4	4	Chemie (6ZP)
3	D, A, B, C	{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid	non-polymer		409.3	4	Chemie (ZK1)
4	D, A, B, C	1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		787.1	14	Chemie (PCW)
5	A, C	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)
6	A, B	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
7		water	water		18.0	15	Chemie (HOH)

Sequence modifications

A, B, C, D: 10 - 826 (UniProt: P19491)

PDB	External Database	Details
Glu 241	Asn 256	conflict
Leu 382	Val 397	conflict
-	Leu 399	deletion
-	Thr 400	deletion
-	Glu 401	deletion
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
Glu 384	Gly 405	conflict
Asp 385	Asn 406	conflict
Gln 392	Asn 413	conflict
Gly 827	-	linker
Thr 828	-	linker
Gly 829	-	linker
Ser 830	-	linker
Ala 831	-	linker

A, B, C, D: 832 - 1035 (UniProt: Q8VHW8)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	459915.4
Non-Polymers*	Number of molecules	26
	Total formula weight	14873.5
All*	Total formula weight	474789.0

*Water molecules are not included.