8SRI
Cryo-EM structure of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, closed state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | TRPM2 chanzyme | polymer | 1494 | 168194.5 | 4 | UniProt (F2UB89) Pfam (PF18139) Pfam (PF00520) | Salpingoeca rosetta | Nudt9 protein |
| 2 | CA, E, HA, K, NA... (C, A, D, B) | ADENOSINE-5-DIPHOSPHORIBOSE | non-polymer | 559.3 | 8 | Chemie (APR) | |||
| 3 | AA, F, G, H, I... (C, A, D, B) | MAGNESIUM ION | non-polymer | 24.3 | 16 | Chemie (MG) | |||
| 4 | BA, DA, EA, FA, GA... (C, D, A, B) | CHOLESTEROL | non-polymer | 386.7 | 12 | Chemie (CLR) |
Sequence modifications
A, B, C, D: 1 - 1494 (UniProt: F2UB89)
| PDB | External Database | Details |
|---|---|---|
| Ala 1114 | Glu 1114 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 672777.8 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 9503.3 | |
| All* | Total formula weight | 682281.1 |
