8SRH
Cryo-EM structure of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, open state
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | TRPM2 chanzyme | polymer | 1494 | 168194.5 | 4 | UniProt (F2UB89) Pfam (PF18139) Pfam (PF00520) In PDB | Salpingoeca rosetta | Nudt9 protein |
2 | C, A, D, B | ADENOSINE-5-DIPHOSPHORIBOSE | non-polymer | 559.3 | 8 | Chemie (APR) | |||
3 | C, A, D, B | MAGNESIUM ION | non-polymer | 24.3 | 16 | Chemie (MG) | |||
4 | C, D, A, B | CHOLESTEROL | non-polymer | 386.7 | 12 | Chemie (CLR) |
Sequence modifications
A, B, C, D: 1 - 1494 (UniProt: F2UB89)
PDB | External Database | Details |
---|---|---|
Ala 1114 | Glu 1114 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 672777.8 | |
Non-Polymers* | Number of molecules | 36 |
Total formula weight | 9503.3 | |
All* | Total formula weight | 682281.1 |