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8SQ9

SARS-CoV-2 replication-transcription complex bound to nsp9 and UMPCPP, as a pre-catalytic NMPylation intermediate

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
RNA-directed RNA polymerasepolymer932106781.01UniProt (P0DTD1)
Pfam (PF06478)
Pfam (PF00680)
Severe acute respiratory syndrome coronavirus 2Pol, RdRp, Non-structural protein 12, nsp12
2B, D
(B, D)
Non-structural protein 8polymer19821903.02UniProt (P0DTD1)
Pfam (PF08717)
Severe acute respiratory syndrome coronavirus 2nsp8
3C
(C)
Non-structural protein 7polymer839248.81UniProt (P0DTD1)
Pfam (PF08716)
Severe acute respiratory syndrome coronavirus 2nsp7
4E
(G)
Non-structural protein 9polymer11312391.21UniProt (P0DTD1)
Pfam (PF08710)
Severe acute respiratory syndrome coronavirus 2nsp9
5F
(P)
Primer RNApolymer3511155.71Severe acute respiratory syndrome coronavirus
6G
(T)
Template RNApolymer5517557.31Severe acute respiratory syndrome coronavirus
7H, I
(A)
ZINC IONnon-polymer65.42Chemie (ZN)
8J, K, M, N
(A)
MAGNESIUM IONnon-polymer24.34Chemie (MG)
PubChem (888)
9L, O
(A)
5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]uridinenon-polymer482.22Chemie (WSB)
PubChem (154724555)
PubChem (155886628)
10P, Q, R, S, T...
(A, B, C, D, P...)
waterwater18.0242Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains7
Total formula weight200940.1
Non-Polymers*Number of molecules8
Total formula weight1192.4
All*Total formula weight202132.4
*Water molecules are not included.

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PDB entries from 2026-04-01

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