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8SQ9

SARS-CoV-2 replication-transcription complex bound to nsp9 and UMPCPP, as a pre-catalytic NMPylation intermediate

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
RNA-directed RNA polymerasepolymer932106781.01UniProt (P0DTD1)
Pfam (PF06478)
Pfam (PF00680)
Severe acute respiratory syndrome coronavirus 2Pol, RdRp, Non-structural protein 12, nsp12
2B, D
(B, D)
Non-structural protein 8polymer19821903.02UniProt (P0DTD1)
Pfam (PF08717)
Severe acute respiratory syndrome coronavirus 2nsp8
3C
(C)
Non-structural protein 7polymer839248.81UniProt (P0DTD1)
Pfam (PF08716)
Severe acute respiratory syndrome coronavirus 2nsp7
4E
(G)
Non-structural protein 9polymer11312391.21UniProt (P0DTD1)
Pfam (PF08710)
Severe acute respiratory syndrome coronavirus 2nsp9
5F
(P)
Primer RNApolymer3511155.71Severe acute respiratory syndrome coronavirus
6G
(T)
Template RNApolymer5517557.31Severe acute respiratory syndrome coronavirus
7H, I
(A)
ZINC IONnon-polymer65.42Chemie (ZN)
8J, K, M, N
(A)
MAGNESIUM IONnon-polymer24.34Chemie (MG)
9L, O
(A)
5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]uridinenon-polymer482.22Chemie (WSB)
10P, Q, R, S, T...
(A, B, C, D, P...)
waterwater18.0242Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains7
Total formula weight200940.1
Non-Polymers*Number of molecules8
Total formula weight1192.4
All*Total formula weight202132.4
*Water molecules are not included.

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PDB entries from 2025-06-11

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