8SOK
Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the presence of telomeric ssDNA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | CST complex subunit CTC1 | polymer | 1613 | 178300.6 | 1 | UniProt (P0AEY0) UniProt (Q2NKJ3) Pfam (PF01547) Pfam (PF15489) UniProt (by SIFTS) (P0AEX9) In PDB | Escherichia coli O157:H7 | Conserved telomere maintenance component 1,HBV DNAPTP1-transactivated protein B |
2 | B | CST complex subunit STN1 | polymer | 368 | 42172.9 | 1 | UniProt (Q9H668) Pfam (PF01336) Pfam (PF09170) In PDB | Homo sapiens (human) | Oligonucleotide/oligosaccharide-binding fold-containing protein 1,Suppressor of cdc thirteen homolog |
3 | C | CST complex subunit TEN1 | polymer | 123 | 13872.0 | 1 | UniProt (Q86WV5) Pfam (PF15490) In PDB | Homo sapiens (human) | Protein telomeric pathways with STN1 homolog,Telomere length regulation protein TEN1 homolog |
4 | D | Protection of telomeres protein 1 | polymer | 646 | 72938.2 | 1 | UniProt (Q9NUX5) Pfam (PF02765) Pfam (PF16686) Pfam (PF21375) In PDB | Homo sapiens (human) | hPot1,POT1-like telomere end-binding protein |
5 | E | TPP1 | polymer | 529 | 58064.9 | 1 | UniProt (B6F2F5) UniProt (Q96AP0) Pfam (PF10341) Pfam (PF01353) In PDB | Human enterovirus 71 (EV71 EV-71) | POT1 and TIN2-interacting protein |
6 | F | DNA (5'-D(*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3') | polymer | 18 | 5682.7 | 1 | synthetic construct | ||
7 | A, D | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A: -381 - -16 (UniProt: P0AEY0)
A: 1 - 1217 (UniProt: Q2NKJ3)
D: 2 - 634 (UniProt: Q9NUX5)
E: -248 - -9 (UniProt: B6F2F5)
E: 1 - 251 (UniProt: Q96AP0)
PDB | External Database | Details |
---|---|---|
Met -395 | - | initiating methionine |
Gly -394 | - | expression tag |
Ser -393 | - | expression tag |
Ser -392 | - | expression tag |
His -391 | - | expression tag |
His -390 | - | expression tag |
His -389 | - | expression tag |
His -388 | - | expression tag |
His -387 | - | expression tag |
His -386 | - | expression tag |
Ser -385 | - | expression tag |
Ser -384 | - | expression tag |
Gly -383 | - | expression tag |
Thr -382 | - | expression tag |
Lys -15 | - | linker |
Leu -14 | - | linker |
Val -13 | - | linker |
Glu -12 | - | linker |
Lys -11 | - | linker |
Tyr -10 | - | linker |
Leu -9 | - | linker |
Glu -8 | - | linker |
Val -7 | - | linker |
Leu -6 | - | linker |
Phe -5 | - | linker |
Gln -4 | - | linker |
Gly -3 | - | linker |
Pro -2 | - | linker |
Gly -1 | - | linker |
Ser 0 | - | linker |
D: 2 - 634 (UniProt: Q9NUX5)
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
Gly 0 | - | expression tag |
Ser 1 | - | expression tag |
Glu 320 | - | insertion |
Ser 320 | - | insertion |
Asp 320 | - | insertion |
Leu 320 | - | insertion |
PDB | External Database | Details |
---|---|---|
Met -277 | - | initiating methionine |
Trp -276 | - | expression tag |
Ser -275 | - | expression tag |
His -274 | - | expression tag |
Pro -273 | - | expression tag |
Gln -272 | - | expression tag |
Phe -271 | - | expression tag |
Glu -270 | - | expression tag |
Lys -269 | - | expression tag |
Gly -268 | - | expression tag |
Gly -267 | - | expression tag |
Gly -266 | - | expression tag |
Ser -265 | - | expression tag |
Gly -264 | - | expression tag |
Gly -263 | - | expression tag |
Gly -262 | - | expression tag |
Ser -261 | - | expression tag |
Gly -260 | - | expression tag |
Gly -259 | - | expression tag |
Ser -258 | - | expression tag |
Ala -257 | - | expression tag |
Trp -256 | - | expression tag |
Ser -255 | - | expression tag |
His -254 | - | expression tag |
Pro -253 | - | expression tag |
Gln -252 | - | expression tag |
Phe -251 | - | expression tag |
Glu -250 | - | expression tag |
Lys -249 | - | expression tag |
Glu -8 | - | linker |
Asn -7 | - | linker |
Leu -6 | - | linker |
Tyr -5 | - | linker |
Phe -4 | - | linker |
Gln -3 | - | linker |
Gly -2 | - | linker |
Gly -1 | - | linker |
Ser 0 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 371031.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 130.8 | |
All* | Total formula weight | 371162.1 |