8SOK

Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the presence of telomeric ssDNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0000781	cellular_component	chromosome, telomeric region
A	0003677	molecular_function	DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005829	cellular_component	cytosol
A	0006974	biological_process	DNA damage response
A	0008643	biological_process	carbohydrate transport
A	0010389	biological_process	regulation of G2/M transition of mitotic cell cycle
A	0010833	biological_process	telomere maintenance via telomere lengthening
A	0015144	molecular_function	carbohydrate transmembrane transporter activity
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0016233	biological_process	telomere capping
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0032211	biological_process	negative regulation of telomere maintenance via telomerase
A	0034219	biological_process	carbohydrate transmembrane transport
A	0034289	biological_process	detection of maltose stimulus
A	0035264	biological_process	multicellular organism growth
A	0042162	molecular_function	telomeric DNA binding
A	0042597	cellular_component	periplasmic space
A	0042956	biological_process	maltodextrin transmembrane transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0045740	biological_process	positive regulation of DNA replication
A	0048146	biological_process	positive regulation of fibroblast proliferation
A	0048536	biological_process	spleen development
A	0048538	biological_process	thymus development
A	0048539	biological_process	bone marrow development
A	0051276	biological_process	chromosome organization
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0060326	biological_process	cell chemotaxis
A	0071425	biological_process	hematopoietic stem cell proliferation
A	0090399	biological_process	replicative senescence
A	0098505	molecular_function	G-rich strand telomeric DNA binding
A	1901982	molecular_function	maltose binding
A	1990060	cellular_component	maltose transport complex
A	1990879	cellular_component	CST complex
B	0000723	biological_process	telomere maintenance
B	0000781	cellular_component	chromosome, telomeric region
B	0001650	cellular_component	fibrillar center
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0010833	biological_process	telomere maintenance via telomere lengthening
B	0016233	biological_process	telomere capping
B	0032211	biological_process	negative regulation of telomere maintenance via telomerase
B	0042162	molecular_function	telomeric DNA binding
B	0043047	molecular_function	single-stranded telomeric DNA binding
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0045111	cellular_component	intermediate filament cytoskeleton
B	0045740	biological_process	positive regulation of DNA replication
B	1990879	cellular_component	CST complex
C	0000781	cellular_component	chromosome, telomeric region
C	0003677	molecular_function	DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0010521	molecular_function	telomerase inhibitor activity
C	0016233	biological_process	telomere capping
C	0032211	biological_process	negative regulation of telomere maintenance via telomerase
C	0042162	molecular_function	telomeric DNA binding
C	1990879	cellular_component	CST complex
D	0000723	biological_process	telomere maintenance
D	0000781	cellular_component	chromosome, telomeric region
D	0003677	molecular_function	DNA binding
D	0043047	molecular_function	single-stranded telomeric DNA binding
E	0000723	biological_process	telomere maintenance
E	0000781	cellular_component	chromosome, telomeric region
E	0000783	cellular_component	nuclear telomere cap complex
E	0005697	cellular_component	telomerase holoenzyme complex
E	0006091	biological_process	generation of precursor metabolites and energy
E	0007004	biological_process	telomere maintenance via telomerase
E	0008218	biological_process	bioluminescence
E	0016233	biological_process	telomere capping
E	0042162	molecular_function	telomeric DNA binding
E	0051973	biological_process	obsolete positive regulation of telomerase activity
E	0070187	cellular_component	shelterin complex

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO-275-ASN-258

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569

Chain	Residue	Details
E	SER25

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