8SG1
Cryo-EM structure of CMKLR1 signaling complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Chemerin-like receptor 1 | polymer | 292 | 33079.7 | 1 | UniProt (Q99788) Pfam (PF00001) | Homo sapiens (human) | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 336 | 36956.4 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 54 | 6000.0 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 351 | 40122.7 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 5 | E (L) | Chemerin 9 | polymer | 9 | 1063.2 | 1 | UniProt (by SIFTS) (Q99969) | Homo sapiens | |
| 6 | F (E) | scFv16 | polymer | 266 | 28634.8 | 1 | Mus musculus (mouse) | ||
| 7 | G (R) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 8 | H, I (R) | PALMITIC ACID | non-polymer | 256.4 | 2 | Chemie (PLM) |
Sequence modifications
G: 9 - 62 (UniProt: P59768)
A: 4 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Gln 17 | Glu 17 | conflict |
| Gln 58 | Glu 58 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | engineered mutation |
| Ala 203 | Gly 203 | engineered mutation |
| Ala 245 | Glu 245 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 145856.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 899.5 | |
| All* | Total formula weight | 146756.2 |
