8SE8

HTRA-1 PD/SA bound to CKP 1G10

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Serine protease HTRA1	polymer	240	26060.8	12	UniProt (Q92743) Pfam (PF13365) In PDB	Homo sapiens (human)	High-temperature requirement A serine peptidase 1,L56,Serine protease 11
2	I, X, Y, G, H...	Cysteine knot peptide	polymer	41	4737.3	12		Ecballium elaterium
3	Y, F, P, A	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5		water	water		18.0	5	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, K, L, M, Q, R, S: 161 - 379 (UniProt: Q92743)

PDB	External Database	Details
Met 140	-	expression tag
Gly 141	-	expression tag
Ser 142	-	expression tag
Ser 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag
His 148	-	expression tag
His 149	-	expression tag
Ser 150	-	expression tag
Ser 151	-	expression tag
Gly 152	-	expression tag
Leu 153	-	expression tag
Val 154	-	expression tag
Pro 155	-	expression tag
Arg 156	-	expression tag
Gly 157	-	expression tag
Ser 158	-	expression tag
His 159	-	expression tag
Met 160	-	expression tag
Ala 328	Ser 328	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	24
	Total formula weight	369578.1
Non-Polymers*	Number of molecules	5
	Total formula weight	476.3
All*	Total formula weight	370054.4

*Water molecules are not included.