8SE8

HTRA-1 PD/SA bound to CKP 1G10

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004252	molecular_function	serine-type endopeptidase activity
D	0006508	biological_process	proteolysis
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
F	0004252	molecular_function	serine-type endopeptidase activity
F	0006508	biological_process	proteolysis
G	0004866	molecular_function	endopeptidase inhibitor activity
H	0004866	molecular_function	endopeptidase inhibitor activity
I	0004866	molecular_function	endopeptidase inhibitor activity
J	0004866	molecular_function	endopeptidase inhibitor activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0006508	biological_process	proteolysis
L	0004252	molecular_function	serine-type endopeptidase activity
L	0006508	biological_process	proteolysis
M	0004252	molecular_function	serine-type endopeptidase activity
M	0006508	biological_process	proteolysis
N	0004866	molecular_function	endopeptidase inhibitor activity
O	0004866	molecular_function	endopeptidase inhibitor activity
P	0004866	molecular_function	endopeptidase inhibitor activity
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0006508	biological_process	proteolysis
R	0004252	molecular_function	serine-type endopeptidase activity
R	0006508	biological_process	proteolysis
S	0004252	molecular_function	serine-type endopeptidase activity
S	0006508	biological_process	proteolysis
T	0004866	molecular_function	endopeptidase inhibitor activity
U	0004866	molecular_function	endopeptidase inhibitor activity
V	0004866	molecular_function	endopeptidase inhibitor activity
X	0004866	molecular_function	endopeptidase inhibitor activity
Y	0004866	molecular_function	endopeptidase inhibitor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:21297635

Chain	Residue	Details
A	HIS220
D	HIS220
D	ASP250
D	ALA328
E	HIS220
E	ASP250
E	ALA328
F	HIS220
F	ASP250
F	ALA328
K	HIS220
A	ASP250
K	ASP250
K	ALA328
L	HIS220
L	ASP250
L	ALA328
M	HIS220
M	ASP250
M	ALA328
Q	HIS220
Q	ASP250
A	ALA328
Q	ALA328
R	HIS220
R	ASP250
R	ALA328
S	HIS220
S	ASP250
S	ALA328
B	HIS220
B	ASP250
B	ALA328
C	HIS220
C	ASP250
C	ALA328

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site_id	SWS_FT_FI2
Number of Residues	36
Details	SITE: Involved in trimer stabilization => ECO:0000269|PubMed:21297635

Chain	Residue	Details
A	TYR169
D	TYR169
D	PHE171
D	PHE278
E	TYR169
E	PHE171
E	PHE278
F	TYR169
F	PHE171
F	PHE278
K	TYR169
A	PHE171
K	PHE171
K	PHE278
L	TYR169
L	PHE171
L	PHE278
M	TYR169
M	PHE171
M	PHE278
Q	TYR169
Q	PHE171
A	PHE278
Q	PHE278
R	TYR169
R	PHE171
R	PHE278
S	TYR169
S	PHE171
S	PHE278
B	TYR169
B	PHE171
B	PHE278
C	TYR169
C	PHE171
C	PHE278

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