8SE6
NKG2D complexed with inhibitor 36
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | NKG2-D type II integral membrane protein | polymer | 129 | 14880.8 | 2 | UniProt (P26718) Pfam (PF00059) In PDB | Homo sapiens (human) | Killer cell lectin-like receptor subfamily K member 1,NK cell receptor D,NKG2-D-activating NK receptor |
| 2 | A, B | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 4 | Chemie (PGE) | |||
| 3 | B | N-[(1S)-2-(dimethylamino)-2-oxo-1-{3-[3-(2,2,2-trifluoroethyl)azetidin-1-yl]phenyl}ethyl]-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide | non-polymer | 563.5 | 1 | Chemie (ZWA) | |||
| 4 | B | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 5 | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A, B: 90 - 216 (UniProt: P26718)
| PDB | External Database | Details |
|---|---|---|
| Met 88 | - | initiating methionine |
| Gly 89 | - | expression tag |
| Glu 117 | Ser 117 | engineered mutation |
| Ser 173 | Ile 173 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29761.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1358.5 | |
| All* | Total formula weight | 31120.1 |
