8SDF

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC25.4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (Z, A)	Spike protein S1	polymer	205	23104.9	2	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2
2	B, E (H, B)	Neutralizing antibody CC25.4 heavy chain	polymer	229	25114.2	2		Homo sapiens (human)
3	C, F (L, C)	Neutralizing antibody CC25.4 light chain	polymer	217	22815.1	2		Homo sapiens (human)
4	G (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
5	H, I, J, K, L... (Z, H, L, A, B...)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	8	Chemie (MPD)
6	M (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
7	Q, R, S, T, U... (Z, H, L, A, B...)	water	water		18.0	780	Chemie (HOH)

Sequence modifications

Z, A: 333 - 530 (UniProt: P0DTC2)

PDB	External Database	Details
Gly 531	-	expression tag
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	142068.2
Branched	Number of molecules	1
	Total formula weight	570.5
Non-Polymers*	Number of molecules	9
	Total formula weight	1166.6
All*	Total formula weight	143805.3

*Water molecules are not included.