8SC7
Structure of EGFR in complex with MTX-531
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 330 | 37563.5 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
4 | A | N-[(5P)-2-chloro-5-(4-{[(1R)-1-phenylethyl]amino}quinazolin-6-yl)pyridin-3-yl]methanesulfonamide | non-polymer | 453.9 | 1 | Chemie (D0D) | |||
5 | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 693 | - | expression tag |
Ala 694 | - | expression tag |
Met 695 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37563.5 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 581.5 | |
All* | Total formula weight | 38144.9 |