8S88
Crystal structure of human L-lactate Dehydrogenase B protein in complex with NADH, oxamate and fluoxetine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | L-lactate dehydrogenase B chain | polymer | 349 | 38602.4 | 12 | UniProt (P07195) Pfam (PF00056) Pfam (PF02866) | Homo sapiens (human) | LDH-B,LDH heart subunit,LDH-H,Renal carcinoma antigen NY-REN-46 |
| 2 | JB, M, QA, R, Z (I, A, F, B, C) | (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine | non-polymer | 309.3 | 5 | Chemie (SFX) | |||
| 3 | AA, CB, GA, KB, N... (C, H, D, I, A...) | OXAMIC ACID | non-polymer | 89.0 | 12 | Chemie (OXM) | |||
| 4 | AC, BA, DB, HA, LB... (L, C, H, D, I...) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 12 | Chemie (NAI) | |||
| 5 | BC, CA, P, TA, WB... (L, C, A, F, K...) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 6 | Chemie (BTB) | |||
| 6 | BB, EA, FA, FC, GC... (G, C, L, D, A...) | SULFATE ION | non-polymer | 96.1 | 12 | Chemie (SO4) | |||
| 7 | AB, CC, DA, DC, EB... (G, L, C, H, D...) | GLYCEROL | non-polymer | 92.1 | 19 | Chemie (GOL) | |||
| 8 | IB, LA, MA, PA, SB... (H, D, E, J, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 7 | Chemie (PEG) | |||
| 9 | HC, IC, JC, KC, LC... (A, B, C, D, E...) | water | water | 18.0 | 1337 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 0 - 333 (UniProt: P07195)
| PDB | External Database | Details |
|---|---|---|
| Glu 334 | - | expression tag |
| Asn 335 | - | expression tag |
| Leu 336 | - | expression tag |
| Tyr 337 | - | expression tag |
| Phe 338 | - | expression tag |
| Gln 339 | - | expression tag |
| Gly 340 | - | expression tag |
| Leu 341 | - | expression tag |
| Glu 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
| His 347 | - | expression tag |
| His 348 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 463229.3 | |
| Non-Polymers* | Number of molecules | 73 |
| Total formula weight | 15501.3 | |
| All* | Total formula weight | 478730.6 |
