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8S0R

Cryo-EM structure of CAK modified by covalent inhibitor SY-1365

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(H)
CDK-activating kinase assembly factor MAT1polymer9310234.51UniProt (P51948)Homo sapiens (human)CDK7/cyclin-H assembly factor,Cyclin-G1-interacting protein,Menage a trois,RING finger protein 66,RING finger protein MAT1,p35,p36
2B
(I)
Cyclin-Hpolymer32437721.51UniProt (P51946)
Pfam (PF00134)
Pfam (PF16899)
Homo sapiens (Human)MO15-associated protein,p34,p37
3C
(J)
Cyclin-dependent kinase 7polymer34939362.61UniProt (P50613)
Pfam (PF00069)
Homo sapiens (human)39 kDa protein kinase,p39 Mo15,CDK-activating kinase 1,Cell division protein kinase 7,Serine/threonine-protein kinase 1,TFIIH basal transcription factor complex kinase subunit
4D
(J)
~{N}-[(1~{S},3~{R})-3-[[5-chloranyl-4-(1~{H}-indol-3-yl)pyrimidin-2-yl]amino]-1-methyl-cyclohexyl]-5-[4-(dimethylamino)butanoylamino]pyridine-2-carboxamidenon-polymer589.11Chemie (A1H46)
5E, F, G
(H, I, J)
waterwater18.0105Chemie (HOH)
Sequence modifications
H: 220 - 309 (UniProt: P51948)
PDBExternal DatabaseDetails
Ser 217-expression tag
Asn 218-expression tag
Ala 219-expression tag
I: 1 - 323 (UniProt: P51946)
PDBExternal DatabaseDetails
Ace 0-acetylation
J: 1 - 346 (UniProt: P50613)
PDBExternal DatabaseDetails
Ser -2-expression tag
Asn -1-expression tag
Ala 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight87318.6
Non-Polymers*Number of molecules1
Total formula weight589.1
All*Total formula weight87907.8
*Water molecules are not included.

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PDB entries from 2025-07-30

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