8RU4
Crystal structure of Human Catenin Beta-1 in complex with stitched peptide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Catenin beta-1 | polymer | 523 | 56984.0 | 2 | UniProt (P35222) Pfam (PF00514) In PDB | Homo sapiens (human) | Beta-catenin |
| 2 | C | Axin-1 | polymer | 13 | 1496.9 | 1 | UniProt (O15169) Pfam (PF08833) In PDB | Homo sapiens | Axis inhibition protein 1,hAxin |
| 3 | A, B | alpha-D-glucopyranose | non-polymer | 180.2 | 7 | Chemie (GLC) | |||
| 4 | A, B | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 4 | Chemie (TRS) | |||
| 5 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | water | water | 18.0 | 328 | Chemie (HOH) |
Sequence modifications
A, B: 145 - 665 (UniProt: P35222)
C: 2 - 12 (UniProt: O15169)
| PDB | External Database | Details |
|---|---|---|
| Gly 143 | - | expression tag |
| Pro 144 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ace 1 | - | acetylation |
| Mh8 2 | Ser 469 | engineered mutation |
| B5i 6 | Glu 473 | engineered mutation |
| Leu 8 | Val 475 | engineered mutation |
| Mh8 9 | Gln 476 | engineered mutation |
| Trp 12 | Leu 479 | engineered mutation |
| Nh2 13 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 115464.9 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1831.1 | |
| All* | Total formula weight | 117296.0 |
