8RRX
Structure of RyR1 reconstituted into lipid nanodisc in primed state in complex with Ca2+, ATP, caffeine and Nb9657
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | H, L, J, F | Peptidyl-prolyl cis-trans isomerase FKBP1B | polymer | 107 | 11667.3 | 4 | UniProt (Q8HYX6) In PDB | Oryctolagus cuniculus (rabbit) | PPIase FKBP1B,12.6 kDa FK506-binding protein,12.6 kDa FKBP,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase |
| 2 | I, A, D, G | Ryanodine receptor 1 | polymer | 5027 | 564931.8 | 4 | UniProt (P11716) In PDB | Oryctolagus cuniculus (rabbit) | RYR-1,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor |
| 3 | K, C, E, M | Nanobody 9657 | polymer | 137 | 15125.5 | 4 | Vicugna pacos | ||
| 4 | G, I, A, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | G, I, A, D | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 4 | Chemie (POV) | |||
| 6 | G, I, A, D | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 7 | G, I, A, D | CAFFEINE | non-polymer | 194.2 | 4 | Chemie (CFF) | |||
| 8 | D, G, I, A | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) |
Sequence modifications
H, L, J, F: 1 - 107 (UniProt: Q8HYX6)
| PDB | External Database | Details |
|---|---|---|
| Asp 100 | Gly 101 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 2366898.2 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 6267.7 | |
| All* | Total formula weight | 2373165.9 |
