8RRX

Structure of RyR1 reconstituted into lipid nanodisc in primed state in complex with Ca2+, ATP, caffeine and Nb9657

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (H, L, J, F)	Peptidyl-prolyl cis-trans isomerase FKBP1B	polymer	107	11667.3	4	UniProt (Q8HYX6) Pfam (PF00254)	Oryctolagus cuniculus (rabbit)	PPIase FKBP1B,12.6 kDa FK506-binding protein,12.6 kDa FKBP,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase
2	B, E, H, K (I, A, D, G)	Ryanodine receptor 1	polymer	5027	564931.8	4	UniProt (P11716) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119)	Oryctolagus cuniculus (rabbit)	RYR-1,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor
3	C, F, I, L (K, C, E, M)	Nanobody 9657	polymer	137	15125.5	4		Vicugna pacos
4	BA, M, S, W (G, I, A, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	CA, N, R, X (G, I, A, D)	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	4	Chemie (POV)
6	DA, O, T, Y (G, I, A, D)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	4	Chemie (ATP)
7	EA, P, U, Z (G, I, A, D)	CAFFEINE	non-polymer		194.2	4	Chemie (CFF)
8	AA, FA, Q, V (D, G, I, A)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)

Sequence modifications

H, L, J, F: 1 - 107 (UniProt: Q8HYX6)

PDB	External Database	Details
Asp 100	Gly 101	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	2366898.2
Non-Polymers*	Number of molecules	20
	Total formula weight	6267.7
All*	Total formula weight	2373165.9

*Water molecules are not included.