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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8RRX

Structure of RyR1 reconstituted into lipid nanodisc in primed state in complex with Ca2+, ATP, caffeine and Nb9657

This is a non-PDB format compatible entry.

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
I	PHE4559-PHE4579
A	PHE4559-PHE4579
D	PHE4559-PHE4579
G	PHE4559-PHE4579

site_id	SWS_FT_FI2
Number of Residues	408
Details	TOPO_DOM: Lumenal => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
I	TYR4580-GLU4640
D	HIS4803
D	ASN4857-MET4879
D	GLU4900-THR4919
G	TYR4580-GLU4640
G	HIS4803
G	ASN4857-MET4879
G	GLU4900-THR4919
I	HIS4803
I	ASN4857-MET4879
I	GLU4900-THR4919
A	TYR4580-GLU4640
A	HIS4803
A	ASN4857-MET4879
A	GLU4900-THR4919
D	TYR4580-GLU4640

site_id	SWS_FT_FI3
Number of Residues	80
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
I	PRO4641-TYR4661
A	PRO4641-TYR4661
D	PRO4641-TYR4661
G	PRO4641-TYR4661

site_id	SWS_FT_FI4
Number of Residues	908
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
I	ASN4662-LYS4779
G	ASN4662-LYS4779
G	LYS4821-LYS4835
G	GLY4941-SER5037
I	LYS4821-LYS4835
I	GLY4941-SER5037
A	ASN4662-LYS4779
A	LYS4821-LYS4835
A	GLY4941-SER5037
D	ASN4662-LYS4779
D	LYS4821-LYS4835
D	GLY4941-SER5037

site_id	SWS_FT_FI5
Number of Residues	88
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
I	PHE4780-GLY4802
A	PHE4780-GLY4802
D	PHE4780-GLY4802
G	PHE4780-GLY4802

site_id	SWS_FT_FI6
Number of Residues	64
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
I	TYR4804-VAL4820
A	TYR4804-VAL4820
D	TYR4804-VAL4820
G	TYR4804-VAL4820

site_id	SWS_FT_FI7
Number of Residues	80
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
I	GLN4836-PHE4856
A	GLN4836-PHE4856
D	GLN4836-PHE4856
G	GLN4836-PHE4856

site_id	SWS_FT_FI8
Number of Residues	76
Details	INTRAMEM: Pore-forming => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
I	MET4880-ASP4899
A	MET4880-ASP4899
D	MET4880-ASP4899
G	MET4880-ASP4899

site_id	SWS_FT_FI9
Number of Residues	80
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:25470059, ECO:0000269\|PubMed:25517095, ECO:0000269\|PubMed:27468892, ECO:0000269\|PubMed:27573175

Chain	Residue	Details
I	PHE4920-PHE4940
A	PHE4920-PHE4940
D	PHE4920-PHE4940
G	PHE4920-PHE4940

site_id	SWS_FT_FI10
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305\|PubMed:27662087, ECO:0007744\|PDB:5TA3, ECO:0007744\|PDB:5TAL, ECO:0007744\|PDB:5TAM, ECO:0007744\|PDB:5TAN

Chain	Residue	Details
I	GLU3893
G	GLU3893
G	GLU3967
G	THR5001
I	GLU3967
I	THR5001
A	GLU3893
A	GLU3967
A	THR5001
D	GLU3893
D	GLU3967
D	THR5001

site_id	SWS_FT_FI11
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305\|PubMed:27662087, ECO:0007744\|PDB:5T9V, ECO:0007744\|PDB:5TA3, ECO:0007744\|PDB:5TAL, ECO:0007744\|PDB:5TAM, ECO:0007744\|PDB:5TAN, ECO:0007744\|PDB:5TAS, ECO:0007744\|PDB:5TAT, ECO:0007744\|PDB:5TAU

Chain	Residue	Details
I	LYS4211
G	LYS4211
G	MET4954
G	THR4979
I	MET4954
I	THR4979
A	LYS4211
A	MET4954
A	THR4979
D	LYS4211
D	MET4954
D	THR4979

site_id	SWS_FT_FI12
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305\|PubMed:27662087, ECO:0007744\|PDB:5TAN

Chain	Residue	Details
I	TRP4716
A	TRP4716
D	TRP4716
G	TRP4716

site_id	SWS_FT_FI13
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:F1LMY4

Chain	Residue	Details
I	SER1338
G	SER1338
G	SER2345
G	SER4470
I	SER2345
I	SER4470
A	SER1338
A	SER2345
A	SER4470
D	SER1338
D	SER2345
D	SER4470

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKA and PKG => ECO:0000269\|PubMed:8380342

Chain	Residue	Details
I	SER2843
A	SER2843
D	SER2843
G	SER2843

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine => ECO:0000269\|PubMed:10601232, ECO:0000269\|PubMed:11562475, ECO:0000269\|PubMed:22036948

Chain	Residue	Details
I	CYS3635
A	CYS3635
D	CYS3635
G	CYS3635

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:F1LMY4

Chain	Residue	Details
I	THR4466
A	THR4466
D	THR4466
G	THR4466

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P21817

Chain	Residue	Details
I	TYR4863
A	TYR4863
D	TYR4863
G	TYR4863

site_id	SWS_FT_FI18
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P21817

Chain	Residue	Details
I	SER4866
A	SER4866
D	SER4866
G	SER4866

227344

PDB entries from 2024-11-13

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