8RQA
Crystal structure of CRBN-midi in complex with Lenalidomide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein cereblon | polymer | 329 | 37478.8 | 1 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) In PDB | Homo sapiens (human) | |
2 | A | S-Lenalidomide | non-polymer | 259.3 | 1 | Chemie (LVY) | |||
3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A: 41 - 187 (UniProt: Q96SW2)
A: 249 - 426 (UniProt: Q96SW2)
PDB | External Database | Details |
---|---|---|
Ser 40 | - | expression tag |
Ile 78 | Cys 78 | engineered mutation |
Val 92 | Ile 92 | engineered mutation |
Asn 116 | Lys 116 | engineered mutation |
Glu 134 | Gln 134 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 188 | - | linker |
Ser 189 | - | linker |
Gly 190 | - | linker |
Trp 283 | Arg 283 | engineered mutation |
Asn 287 | Cys 287 | engineered mutation |
Ser 293 | Val 293 | engineered mutation |
Asp 302 | Gly 302 | engineered mutation |
Arg 342 | Leu 342 | engineered mutation |
Glu 343 | Cys 343 | engineered mutation |
Ile 359 | Thr 359 | engineered mutation |
Ile 423 | Leu 423 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37478.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 324.7 | |
All* | Total formula weight | 37803.5 |