8ROE
Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - ADP-bound conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Structural maintenance of chromosomes protein 1A | polymer | 366 | 40665.1 | 1 | UniProt (Q14683) Pfam (PF02463) | Homo sapiens (human) | SMC protein 1A,SMC-1-alpha,SMC-1A,Sb1.8 |
| 2 | B (B) | 64-kDa C-terminal product | polymer | 81 | 9203.6 | 1 | UniProt (O60216) Pfam (PF04824) | Homo sapiens (human) | 64-kDa carboxy-terminal product,65-kDa carboxy-terminal product |
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 301 | Chemie (HOH) |
Sequence modifications
A: 1 - 175 (UniProt: Q14683)
A: 1057 - 1233 (UniProt: Q14683)
B: 558 - 629 (UniProt: O60216)
A: 1057 - 1233 (UniProt: Q14683)
| PDB | External Database | Details |
|---|---|---|
| Gly 176 | - | linker |
| Ser 177 | - | linker |
| Gly 178 | - | linker |
| Ser 179 | - | linker |
| Leu 180 | - | linker |
| Val 181 | - | linker |
| Pro 182 | - | linker |
| Arg 183 | - | linker |
| Gly 184 | - | linker |
| Ser 185 | - | linker |
| Gly 1053 | - | linker |
| Ser 1054 | - | linker |
| Ala 1055 | - | linker |
| Lys 1056 | - | linker |
| Gln 1157 | Glu 1157 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 557 | - | initiating methionine |
| Gly 630 | - | expression tag |
| Ser 631 | - | expression tag |
| Leu 632 | - | expression tag |
| Glu 633 | - | expression tag |
| Val 634 | - | expression tag |
| Leu 635 | - | expression tag |
| Phe 636 | - | expression tag |
| Gln 637 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49868.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 427.2 | |
| All* | Total formula weight | 50296.0 |
