8RO9
Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - Open/closed P-loop conformation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Structural maintenance of chromosomes protein 1A | polymer | 456 | 51443.2 | 2 | UniProt (Q14683) In PDB | Homo sapiens (human) | SMC protein 1A,SMC-1-alpha,SMC-1A,Sb1.8 |
2 | B, D | 64-kDa C-terminal product | polymer | 81 | 9203.6 | 2 | UniProt (O60216) In PDB | Homo sapiens (human) | 64-kDa carboxy-terminal product,65-kDa carboxy-terminal product |
3 | A | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) | |||
4 | water | water | 18.0 | 389 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 977 (UniProt: Q14683)
A, C: 992 - 1233 (UniProt: Q14683)
B, D: 558 - 629 (UniProt: O60216)
A, C: 992 - 1233 (UniProt: Q14683)
PDB | External Database | Details |
---|---|---|
Glu 978 | - | linker |
Ser 979 | - | linker |
Ser 980 | - | linker |
Lys 981 | - | linker |
His 982 | - | linker |
Pro 983 | - | linker |
Thr 984 | - | linker |
Ser 985 | - | linker |
Leu 986 | - | linker |
Val 987 | - | linker |
Pro 988 | - | linker |
Arg 989 | - | linker |
Gly 990 | - | linker |
Ser 991 | - | linker |
Gln 1157 | Glu 1157 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 557 | - | initiating methionine |
Gly 630 | - | expression tag |
Ser 631 | - | expression tag |
Leu 632 | - | expression tag |
Glu 633 | - | expression tag |
Val 634 | - | expression tag |
Leu 635 | - | expression tag |
Phe 636 | - | expression tag |
Gln 637 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 121293.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 282.3 | |
All* | Total formula weight | 121576.1 |