8RO2
Integrative Structure of the human intron lariat Spliceosome (ILS'')
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | U2 snRNA | polymer | 188 | 60186.4 | 1 | GenBank (36516) | Homo sapiens (human) | |
| 2 | B (6) | U6 snRNA | polymer | 106 | 34098.3 | 1 | GenBank (NR_004394.1) | Homo sapiens (human) | |
| 3 | C (C) | 116 kDa U5 small nuclear ribonucleoprotein component | polymer | 972 | 109560.6 | 1 | UniProt (Q15029) Pfam (PF16004) Pfam (PF00009) Pfam (PF03144) Pfam (PF14492) Pfam (PF03764) Pfam (PF00679) | Homo sapiens (human) | Elongation factor Tu GTP-binding domain-containing protein 2,SNU114 homolog,hSNU114,U5 snRNP-specific protein,116 kDa,U5-116 kDa |
| 4 | D (D) | Pre-mRNA-splicing factor ISY1 homolog | polymer | 285 | 33046.3 | 1 | UniProt (Q9ULR0) Pfam (PF06246) | Homo sapiens (human) | |
| 5 | E (DX) | ATP-dependent RNA helicase DHX15 | polymer | 795 | 91065.8 | 1 | UniProt (O43143) Pfam (PF00270) Pfam (PF00271) Pfam (PF04408) Pfam (PF21010) Pfam (PF07717) | Homo sapiens (human) | ATP-dependent RNA helicase #46,DEAH box protein 15,Splicing factor Prp43,hPrp43 |
| 6 | F (E) | U5 small nuclear ribonucleoprotein 40 kDa protein | polymer | 357 | 39359.5 | 1 | UniProt (Q96DI7) Pfam (PF00400) | Homo sapiens (human) | U5-40K,38 kDa-splicing factor,Prp8-binding protein,hPRP8BP,U5 snRNP-specific 40 kDa protein,WD repeat-containing protein 57 |
| 7 | G (J) | Crooked neck-like protein 1 | polymer | 848 | 100610.0 | 1 | UniProt (Q9BZJ0) Pfam (PF23231) | Homo sapiens (human) | Crooked neck homolog,hCrn |
| 8 | H (K) | Pre-mRNA-splicing factor SPF27 | polymer | 225 | 26163.4 | 1 | UniProt (O75934) Pfam (PF05700) | Homo sapiens (human) | Breast carcinoma-amplified sequence 2,DNA amplified in mammary carcinoma 1 protein,Spliceosome-associated protein SPF 27 |
| 9 | I (L1) | CWF19-like protein 1 | polymer | 538 | 60696.9 | 1 | UniProt (Q69YN2) Pfam (PF04677) Pfam (PF04676) | Homo sapiens (human) | C19L1 |
| 10 | J (N) | Protein BUD31 homolog | polymer | 144 | 17032.8 | 1 | UniProt (P41223) Pfam (PF01125) | Homo sapiens (human) | Protein EDG-2,Protein G10 homolog |
| 11 | K (O) | Pre-mRNA-splicing factor RBM22 | polymer | 420 | 46959.6 | 1 | UniProt (Q9NW64) Pfam (PF21369) Pfam (PF25584) Pfam (PF00076) | Homo sapiens (human) | RNA-binding motif protein 22,Zinc finger CCCH domain-containing protein 16 |
| 12 | L (Q) | Intron-binding protein aquarius | polymer | 1485 | 171502.5 | 1 | UniProt (O60306) Pfam (PF16399) Pfam (PF21143) Pfam (PF21144) Pfam (PF13086) Pfam (PF13087) | Homo sapiens (human) | Intron-binding protein of 160 kDa,IBP160 |
| 13 | M (R) | SNW domain-containing protein 1 | polymer | 536 | 61770.6 | 1 | UniProt (Q13573) Pfam (PF02731) | Homo sapiens (human) | Nuclear protein SkiP,Nuclear receptor coactivator NCoA-62,Ski-interacting protein |
| 14 | N (S) | Peptidyl-prolyl cis-trans isomerase-like 1 | polymer | 166 | 18257.8 | 1 | UniProt (Q9Y3C6) Pfam (PF00160) | Homo sapiens (human) | PPIase,Rotamase PPIL1 |
| 15 | O (W) | Pre-mRNA-processing factor 17 | polymer | 579 | 65612.2 | 1 | UniProt (O60508) Pfam (PF00400) | Homo sapiens (human) | Cell division cycle 40 homolog,EH-binding protein 3,Ehb3,PRP17 homolog,hPRP17 |
| 16 | P (Z) | Coiled-coil domain-containing protein 12 | polymer | 166 | 19223.8 | 1 | UniProt (Q8WUD4) Pfam (PF08315) | Homo sapiens (human) | |
| 17 | Q (a) | Small nuclear ribonucleoprotein Sm D3 | polymer | 126 | 13940.3 | 1 | UniProt (P62318) Pfam (PF01423) | Homo sapiens (human) | Sm-D3,snRNP core protein D3 |
| 18 | R (c) | Small nuclear ribonucleoprotein Sm D1 | polymer | 119 | 13310.7 | 1 | UniProt (P62314) Pfam (PF01423) | Homo sapiens (human) | Sm-D1,Sm-D autoantigen,snRNP core protein D1 |
| 19 | S (d) | Small nuclear ribonucleoprotein Sm D2 | polymer | 118 | 13551.9 | 1 | UniProt (P62316) Pfam (PF01423) | Homo sapiens (human) | Sm-D2,snRNP core protein D2 |
| 20 | T (e) | Small nuclear ribonucleoprotein E | polymer | 92 | 10817.6 | 1 | UniProt (P62304) Pfam (PF01423) | Homo sapiens (human) | snRNP-E,Sm protein E,SmE |
| 21 | U (f) | Small nuclear ribonucleoprotein F | polymer | 86 | 9734.2 | 1 | UniProt (P62306) Pfam (PF01423) | Homo sapiens (human) | snRNP-F,Sm protein F,SmF |
| 22 | V (g) | Small nuclear ribonucleoprotein G | polymer | 76 | 8508.1 | 1 | UniProt (P62308) Pfam (PF01423) | Homo sapiens (human) | snRNP-G,Sm protein G,SmG |
| 23 | LA, MA, NA, W (s, q, r, t) | Pre-mRNA-processing factor 19 | polymer | 504 | 55245.5 | 4 | UniProt (Q9UMS4) Pfam (PF04564) Pfam (PF08606) Pfam (PF24814) | Homo sapiens (human) | Nuclear matrix protein 200,PRP19/PSO4 homolog,hPso4,RING-type E3 ubiquitin transferase PRP19,Senescence evasion factor |
| 24 | X (z) | Splicing regulator SDE2 | polymer | 451 | 49818.0 | 1 | UniProt (Q6IQ49) Pfam (PF22781) Pfam (PF22782) Pfam (PF13297) | Homo sapiens (human) | Replication stress response regulator SDE2 |
| 25 | Y (3) | Splicing factor ESS-2 homolog | polymer | 476 | 52640.0 | 1 | UniProt (Q96DF8) Pfam (PF09751) | Homo sapiens (human) | DiGeorge syndrome critical region 13,DiGeorge syndrome critical region 14,DiGeorge syndrome protein H,DGS-H,Protein ES2 |
| 26 | Z (5) | U5 snRNA | polymer | 116 | 36908.7 | 1 | GenBank (36515) | Homo sapiens (human) | |
| 27 | AA (A) | Pre-mRNA-processing-splicing factor 8 | polymer | 2335 | 273974.3 | 1 | UniProt (Q6P2Q9) Pfam (PF08082) Pfam (PF08083) Pfam (PF10598) Pfam (PF10597) Pfam (PF10596) Pfam (PF12134) Pfam (PF01398) Pfam (PF08084) | Homo sapiens (human) | 220 kDa U5 snRNP-specific protein,PRP8 homolog,Splicing factor Prp8,p220 |
| 28 | BA (I) | Pre-mRNA-splicing factor SYF1 | polymer | 855 | 100148.7 | 1 | UniProt (Q9HCS7) Pfam (PF23233) Pfam (PF23220) Pfam (PF23231) | Homo sapiens (human) | Protein HCNP,XPA-binding protein 2 |
| 29 | CA (IN) | INTRON | polymer | 154 | 30153.6 | 1 | Homo sapiens | ||
| 30 | DA (L) | Cell division cycle 5-like protein | polymer | 802 | 92406.9 | 1 | UniProt (Q99459) Pfam (PF13921) Pfam (PF11831) | Homo sapiens (human) | Cdc5-like protein,Pombe cdc5-related protein |
| 31 | EA (L2) | CWF19-like protein 2 | polymer | 894 | 103976.5 | 1 | UniProt (Q2TBE0) Pfam (PF04677) Pfam (PF04676) | Homo sapiens (human) | |
| 32 | FA (M) | Pre-mRNA-splicing factor SYF2 | polymer | 243 | 28780.5 | 1 | UniProt (O95926) Pfam (PF08231) | Homo sapiens (human) | CCNDBP1-interactor,p29 |
| 33 | GA (P) | Spliceosome-associated protein CWC15 homolog | polymer | 229 | 26674.4 | 1 | UniProt (Q9P013) Pfam (PF04889) | Homo sapiens (human) | |
| 34 | HA (PX) | PAX3- and PAX7-binding protein 1 | polymer | 917 | 104953.7 | 1 | UniProt (Q9Y5B6) Pfam (PF07842) | Homo sapiens (human) | GC-rich sequence DNA-binding factor 1 |
| 35 | IA (T) | Pleiotropic regulator 1 | polymer | 514 | 57280.8 | 1 | UniProt (O43660) Pfam (PF00400) | Homo sapiens (human) | |
| 36 | JA (TF) | Tuftelin-interacting protein 11 | polymer | 837 | 96945.7 | 1 | UniProt (Q9UBB9) Pfam (PF12457) Pfam (PF01585) Pfam (PF07842) | Homo sapiens (human) | Septin and tuftelin-interacting protein 1,STIP-1 |
| 37 | KA (b) | Small nuclear ribonucleoprotein-associated proteins B and B' | polymer | 240 | 24642.1 | 1 | UniProt (P14678) Pfam (PF01423) | Homo sapiens (human) | snRNP-B,Sm protein B/B',SmB/B' |
| 38 | OA (C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 39 | PA, QA, RA (N) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 40 | SA (A) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 40 |
| Total formula weight | 2325295.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1379.4 | |
| All* | Total formula weight | 2326674.8 |
