8RO2
Integrative Structure of the human intron lariat Spliceosome (ILS'')
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00170 |
| Number of Residues | 18 |
| Details | CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YngTkFHRIIkdFMiQGG |
| Chain | Residue | Details |
| S | TYR48-GLY65 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATAadDsSVKLWDL |
| Chain | Residue | Details |
| q | LEU407-LEU421 | |
| T | LEU303-VAL317 | |
| T | ILE345-LEU359 | |
| W | LEU304-VAL318 | |
| E | LEU81-VAL95 | |
| E | LEU124-SER138 | |
| E | VAL167-ILE181 | |
| E | ILE208-LEU222 | |
| E | ILE300-THR314 |
| site_id | PS00690 |
| Number of Residues | 10 |
| Details | DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. GvIILDEAHE |
| Chain | Residue | Details |
| DX | GLY255-GLU264 |
| site_id | PS00997 |
| Number of Residues | 23 |
| Details | G10_1 G10 protein signature 1. LCClRCiqtrDtNfgtnCiCRVP |
| Chain | Residue | Details |
| N | LEU100-PRO122 |
| site_id | PS00998 |
| Number of Residues | 10 |
| Details | G10_2 G10 protein signature 2. CtHCGCRGCS |
| Chain | Residue | Details |
| N | CYS134-SER143 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| K | ALA2 | |
| b | ARG112 | |
| L2 | SER372 | |
| t | SER2 | |
| S | THR119 | |
| S | LYS125 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| K | SER94 | |
| T | SER201 | |
| T | SER391 | |
| q | LYS261 | |
| r | LYS122 | |
| r | LYS261 | |
| t | LYS122 | |
| t | LYS261 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| DX | LYS488 | |
| E | LYS270 | |
| q | LYS179 | |
| q | LYS244 | |
| r | LYS179 | |
| r | LYS244 | |
| t | LYS179 | |
| t | LYS244 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| DX | LYS786 | |
| 3 | SER395 | |
| d | LYS8 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| TF | SER210 | |
| L2 | LYS604 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| PX | SER295 | |
| R | LYS416 | |
| R | LYS441 | |
| R | LYS452 | |
| R | LYS115 | |
| R | LYS122 | |
| R | LYS141 | |
| R | LYS158 | |
| R | LYS258 | |
| R | LYS286 | |
| R | LYS339 | |
| R | LYS344 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| PX | SER557 | |
| PX | SER558 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P58501 |
| Chain | Residue | Details |
| PX | THR563 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| PX | LYS149 | |
| L | THR411 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| L | THR415 | |
| L | THR442 | |
| R | LYS240 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:18583928, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| L | SER417 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:18583928, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| L | THR424 | |
| L | THR438 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| L | THR430 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| L | SER437 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| L | LYS135 | |
| L | LYS487 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| L | LYS219 |
