8RO0
Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS')
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | U2 snRNA | polymer | 191 | 56554.5 | 1 | GenBank (6851) | Caenorhabditis elegans | |
| 2 | B (5) | U5 snRNA | polymer | 121 | 38680.8 | 1 | GenBank (1200267) | Caenorhabditis elegans | |
| 3 | C (6) | U6 snRNA | polymer | 101 | 32483.4 | 1 | GenBank (6866) | Caenorhabditis elegans | |
| 4 | D (A) | Pre-mRNA-splicing factor 8 homolog | polymer | 2329 | 272396.2 | 1 | UniProt (P34369) Pfam (PF08082) Pfam (PF08083) Pfam (PF10598) Pfam (PF10597) Pfam (PF10596) Pfam (PF12134) Pfam (PF01398) Pfam (PF08084) | Caenorhabditis elegans | |
| 5 | E (B) | U5 small nuclear ribonucleoprotein 200 kDa helicase | polymer | 2145 | 244151.6 | 1 | UniProt (Q9U2G0) Pfam (PF18149) Pfam (PF00270) Pfam (PF00271) Pfam (PF02889) Pfam (PF21188) | Caenorhabditis elegans | BRR2 homolog |
| 6 | F (C) | Tr-type G domain-containing protein | polymer | 974 | 110612.9 | 1 | UniProt (Q23463) Pfam (PF16004) Pfam (PF00009) Pfam (PF03144) Pfam (PF03764) Pfam (PF00679) | Caenorhabditis elegans | |
| 7 | G (D) | Protein isy-1 | polymer | 267 | 31326.2 | 1 | UniProt (Q20716) Pfam (PF06246) | Caenorhabditis elegans | |
| 8 | H (E) | WD_REPEATS_REGION domain-containing protein | polymer | 331 | 36865.6 | 1 | UniProt (Q19211) Pfam (PF00400) | Caenorhabditis elegans | |
| 9 | I (I) | Pre-mRNA-splicing factor SYF1 | polymer | 855 | 99675.1 | 1 | UniProt (P91175) Pfam (PF13181) | Caenorhabditis elegans | |
| 10 | J (J) | TPR_REGION domain-containing protein | polymer | 744 | 88116.0 | 1 | UniProt (O16376) Pfam (PF02184) | Caenorhabditis elegans | |
| 11 | K (K) | Pre-mRNA-splicing factor SPF27 | polymer | 238 | 27679.9 | 1 | UniProt (Q22417) Pfam (PF05700) | Caenorhabditis elegans | |
| 12 | L (L) | Cell division cycle 5-like protein | polymer | 755 | 85843.5 | 1 | UniProt (G5EFC4) Pfam (PF13921) Pfam (PF11831) | Caenorhabditis elegans | |
| 13 | M (M) | Pre-mRNA-splicing factor syf-2 | polymer | 234 | 27719.0 | 1 | UniProt (Q09385) Pfam (PF08231) | Caenorhabditis elegans | |
| 14 | N (N) | Protein BUD31 homolog | polymer | 147 | 17153.9 | 1 | UniProt (P34313) Pfam (PF01125) | Caenorhabditis elegans | Protein G10 homolog |
| 15 | O (O) | Pre-mRNA-splicing factor RBM22 | polymer | 408 | 45902.8 | 1 | UniProt (Q22412) Pfam (PF21369) Pfam (PF16131) Pfam (PF00076) | Caenorhabditis elegans | RNA-binding motif protein 22 |
| 16 | P (P) | Spliceosome-associated protein CWC15 homolog | polymer | 230 | 26154.8 | 1 | UniProt (O45766) Pfam (PF04889) | Caenorhabditis elegans | |
| 17 | Q (PX) | GCF C-terminal domain-containing protein | polymer | 809 | 94244.9 | 1 | UniProt (G5ECH1) Pfam (PF15458) Pfam (PF07842) | Caenorhabditis elegans | |
| 18 | R (Q) | Intron-binding protein aquarius | polymer | 1467 | 170397.7 | 1 | UniProt (Q9U1Q7) Pfam (PF16399) Pfam (PF21143) Pfam (PF21144) Pfam (PF13086) Pfam (PF13087) | Caenorhabditis elegans | |
| 19 | S (R) | Uncharacterized protein T27F2.1 | polymer | 535 | 60303.5 | 1 | UniProt (Q22836) Pfam (PF02731) | Caenorhabditis elegans | |
| 20 | T (S) | Peptidyl-prolyl cis-trans isomerase | polymer | 169 | 18547.0 | 1 | UniProt (Q18445) Pfam (PF00160) | Caenorhabditis elegans | PPIase |
| 21 | U (T) | WD_REPEATS_REGION domain-containing protein | polymer | 494 | 54766.2 | 1 | UniProt (G5EEL2) Pfam (PF00400) | Caenorhabditis elegans | |
| 22 | V (TF) | Septin and tuftelin-interacting protein 1 homolog | polymer | 830 | 94421.5 | 1 | UniProt (Q17784) Pfam (PF12457) Pfam (PF01585) Pfam (PF07842) | Caenorhabditis elegans | STIP-1 |
| 23 | W (W) | WD_REPEATS_REGION domain-containing protein | polymer | 567 | 65385.7 | 1 | UniProt (O44729) Pfam (PF00400) | Caenorhabditis elegans | |
| 24 | X (Z) | Coiled-coil domain-containing protein 12 | polymer | 169 | 19138.5 | 1 | UniProt (Q95XJ1) Pfam (PF08315) | Caenorhabditis elegans | |
| 25 | FA, Y (a, h) | Small nuclear ribonucleoprotein Sm D3 | polymer | 136 | 14836.2 | 2 | UniProt (Q17348) Pfam (PF01423) | Caenorhabditis elegans | Sm-D3,snRNP core protein D3 |
| 26 | GA, Z (b, i) | Probable small nuclear ribonucleoprotein-associated protein B | polymer | 160 | 16768.6 | 2 | UniProt (P91918) Pfam (PF01423) | Caenorhabditis elegans | snRNP-B,Sm protein B,Sm-B,SmB |
| 27 | AA, HA (c, j) | Small nuclear ribonucleoprotein Sm D1 | polymer | 127 | 13724.1 | 2 | UniProt (E3LR34) Pfam (PF01423) UniProt (by SIFTS) (Q10013) | Caenorhabditis elegans | snRNP core protein D1 |
| 28 | BA, IA (d, k) | Probable small nuclear ribonucleoprotein Sm D2 | polymer | 118 | 13291.5 | 2 | UniProt (Q18786) Pfam (PF01423) | Caenorhabditis elegans | Sm-D2,snRNP core protein D2 |
| 29 | CA, JA (e, l) | Probable small nuclear ribonucleoprotein E | polymer | 90 | 10625.3 | 2 | UniProt (Q9XTU6) Pfam (PF01423) | Caenorhabditis elegans | snRNP-E,Sm protein E,Sm-E,SmE |
| 30 | DA, KA (f, m) | Probable small nuclear ribonucleoprotein F | polymer | 85 | 9256.5 | 2 | UniProt (P34659) Pfam (PF01423) | Caenorhabditis elegans | snRNP-F,Sm protein F,Sm-F,SmF |
| 31 | EA, LA (g, n) | Probable small nuclear ribonucleoprotein G | polymer | 77 | 8756.2 | 2 | UniProt (Q9N4G9) Pfam (PF01423) | Caenorhabditis elegans | snRNP-G,Sm protein G,Sm-G,SmG |
| 32 | MA (o) | Probable U2 small nuclear ribonucleoprotein A' | polymer | 253 | 28905.9 | 1 | UniProt (Q9BLB6) Pfam (PF12799) | Caenorhabditis elegans | U2 snRNP A',Masculinization of germline protein 2,Spliceosome-associated protein mog-2 |
| 33 | NA (p) | RRM domain-containing protein | polymer | 217 | 24881.3 | 1 | UniProt (Q21323) Pfam (PF00076) | Caenorhabditis elegans | |
| 34 | OA, PA, QA, RA (q, r, s, t) | Pre-mRNA-processing factor 19 | polymer | 492 | 53272.6 | 4 | UniProt (Q10051) Pfam (PF04564) Pfam (PF08606) Pfam (PF00400) | Caenorhabditis elegans | PRP19/PSO4 homolog,RING-type E3 ubiquitin transferase PRP19 |
| 35 | SA (y) | Peptidyl-prolyl cis-trans isomerase E | polymer | 331 | 36469.3 | 1 | UniProt (Q9U2S6) Pfam (PF00076) Pfam (PF00160) | Caenorhabditis elegans | PPIase E |
| 36 | TA (In) | Intron lariat RNA | polymer | 19 | 3680.8 | 1 | Caenorhabditis elegans | ||
| 37 | CB, UA, VA, WA, XA... (C, 6) | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) | |||
| 38 | AB, DB (A, J) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 2 | Chemie (IHP) | |||
| 39 | BB (C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 40 | EB, FB, GB, HB, IB... (N, O) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 46 |
| Total formula weight | 2300065.9 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2405.8 | |
| All* | Total formula weight | 2302471.7 |
