8RO0

Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS')

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000243	cellular_component	commitment complex
a	0000387	biological_process	spliceosomal snRNP assembly
a	0003723	molecular_function	RNA binding
a	0005634	cellular_component	nucleus
a	0005681	cellular_component	spliceosomal complex
a	0005682	cellular_component	U5 snRNP
a	0005685	cellular_component	U1 snRNP
a	0005686	cellular_component	U2 snRNP
a	0005687	cellular_component	U4 snRNP
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0006396	biological_process	RNA processing
a	0006397	biological_process	mRNA processing
a	0008380	biological_process	RNA splicing
a	0034719	cellular_component	SMN-Sm protein complex
a	0043186	cellular_component	P granule
a	0071011	cellular_component	precatalytic spliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	0097526	cellular_component	spliceosomal tri-snRNP complex
a	1990904	cellular_component	ribonucleoprotein complex
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000393	biological_process	spliceosomal conformational changes to generate catalytic conformation
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0000974	cellular_component	Prp19 complex
A	0003723	molecular_function	RNA binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0017070	molecular_function	U6 snRNA binding
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0045292	biological_process	mRNA cis splicing, via spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0097157	molecular_function	pre-mRNA intronic binding
A	1990904	cellular_component	ribonucleoprotein complex
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0005634	cellular_component	nucleus
b	0005681	cellular_component	spliceosomal complex
b	0005682	cellular_component	U5 snRNP
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0070990	molecular_function	snRNP binding
b	0071004	cellular_component	U2-type prespliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	1990904	cellular_component	ribonucleoprotein complex
B	0000166	molecular_function	nucleotide binding
B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B	0000393	biological_process	spliceosomal conformational changes to generate catalytic conformation
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0003724	molecular_function	RNA helicase activity
B	0004386	molecular_function	helicase activity
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005681	cellular_component	spliceosomal complex
B	0005682	cellular_component	U5 snRNP
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
c	0000387	biological_process	spliceosomal snRNP assembly
c	0003723	molecular_function	RNA binding
c	0006396	biological_process	RNA processing
C	0000166	molecular_function	nucleotide binding
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0030623	molecular_function	U5 snRNA binding
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0046872	molecular_function	metal ion binding
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0003723	molecular_function	RNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005681	cellular_component	spliceosomal complex
d	0005682	cellular_component	U5 snRNP
d	0005685	cellular_component	U1 snRNP
d	0005686	cellular_component	U2 snRNP
d	0005689	cellular_component	U12-type spliceosomal complex
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0006397	biological_process	mRNA processing
d	0008380	biological_process	RNA splicing
d	0030532	cellular_component	small nuclear ribonucleoprotein complex
d	0034715	cellular_component	pICln-Sm protein complex
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	0097525	cellular_component	spliceosomal snRNP complex
d	1990904	cellular_component	ribonucleoprotein complex
D	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
D	0000389	biological_process	mRNA 3'-splice site recognition
D	0000974	cellular_component	Prp19 complex
D	0005634	cellular_component	nucleus
D	0071013	cellular_component	catalytic step 2 spliceosome
D	0071014	cellular_component	post-mRNA release spliceosomal complex
D	0071020	cellular_component	post-spliceosomal complex
D	2000634	biological_process	regulation of primary miRNA processing
e	0000387	biological_process	spliceosomal snRNP assembly
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005634	cellular_component	nucleus
e	0005681	cellular_component	spliceosomal complex
e	0005682	cellular_component	U5 snRNP
e	0005685	cellular_component	U1 snRNP
e	0005686	cellular_component	U2 snRNP
e	0005687	cellular_component	U4 snRNP
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0006397	biological_process	mRNA processing
e	0008380	biological_process	RNA splicing
e	0034715	cellular_component	pICln-Sm protein complex
e	0043186	cellular_component	P granule
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0071011	cellular_component	precatalytic spliceosome
e	1990904	cellular_component	ribonucleoprotein complex
E	0000375	biological_process	RNA splicing, via transesterification reactions
E	0005634	cellular_component	nucleus
E	0005681	cellular_component	spliceosomal complex
E	0005682	cellular_component	U5 snRNP
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0071013	cellular_component	catalytic step 2 spliceosome
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005681	cellular_component	spliceosomal complex
f	0005685	cellular_component	U1 snRNP
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0006397	biological_process	mRNA processing
f	0008380	biological_process	RNA splicing
f	0034715	cellular_component	pICln-Sm protein complex
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0120114	cellular_component	Sm-like protein family complex
f	1990904	cellular_component	ribonucleoprotein complex
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003723	molecular_function	RNA binding
g	0005634	cellular_component	nucleus
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005689	cellular_component	U12-type spliceosomal complex
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0006397	biological_process	mRNA processing
g	0008380	biological_process	RNA splicing
g	0034719	cellular_component	SMN-Sm protein complex
g	0043186	cellular_component	P granule
g	0071004	cellular_component	U2-type prespliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1990904	cellular_component	ribonucleoprotein complex
h	0000243	cellular_component	commitment complex
h	0000387	biological_process	spliceosomal snRNP assembly
h	0003723	molecular_function	RNA binding
h	0005634	cellular_component	nucleus
h	0005681	cellular_component	spliceosomal complex
h	0005682	cellular_component	U5 snRNP
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0006396	biological_process	RNA processing
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0034719	cellular_component	SMN-Sm protein complex
h	0043186	cellular_component	P granule
h	0071011	cellular_component	precatalytic spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	0097526	cellular_component	spliceosomal tri-snRNP complex
h	1990904	cellular_component	ribonucleoprotein complex
i	0000398	biological_process	mRNA splicing, via spliceosome
i	0003723	molecular_function	RNA binding
i	0005634	cellular_component	nucleus
i	0005681	cellular_component	spliceosomal complex
i	0005682	cellular_component	U5 snRNP
i	0005685	cellular_component	U1 snRNP
i	0005686	cellular_component	U2 snRNP
i	0005687	cellular_component	U4 snRNP
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0006397	biological_process	mRNA processing
i	0008380	biological_process	RNA splicing
i	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0070990	molecular_function	snRNP binding
i	0071004	cellular_component	U2-type prespliceosome
i	0071013	cellular_component	catalytic step 2 spliceosome
i	1990904	cellular_component	ribonucleoprotein complex
I	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0000974	cellular_component	Prp19 complex
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005681	cellular_component	spliceosomal complex
I	0006396	biological_process	RNA processing
I	0006397	biological_process	mRNA processing
I	0008380	biological_process	RNA splicing
I	0071007	cellular_component	U2-type catalytic step 2 spliceosome
I	0071014	cellular_component	post-mRNA release spliceosomal complex
j	0000387	biological_process	spliceosomal snRNP assembly
j	0003723	molecular_function	RNA binding
j	0006396	biological_process	RNA processing
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0005634	cellular_component	nucleus
J	0006396	biological_process	RNA processing
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005681	cellular_component	spliceosomal complex
k	0005682	cellular_component	U5 snRNP
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005689	cellular_component	U12-type spliceosomal complex
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0006397	biological_process	mRNA processing
k	0008380	biological_process	RNA splicing
k	0030532	cellular_component	small nuclear ribonucleoprotein complex
k	0034715	cellular_component	pICln-Sm protein complex
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0071011	cellular_component	precatalytic spliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	0097525	cellular_component	spliceosomal snRNP complex
k	1990904	cellular_component	ribonucleoprotein complex
K	0000974	cellular_component	Prp19 complex
K	0005634	cellular_component	nucleus
K	0005681	cellular_component	spliceosomal complex
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0071013	cellular_component	catalytic step 2 spliceosome
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0005634	cellular_component	nucleus
l	0005681	cellular_component	spliceosomal complex
l	0005682	cellular_component	U5 snRNP
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005687	cellular_component	U4 snRNP
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0006397	biological_process	mRNA processing
l	0008380	biological_process	RNA splicing
l	0034715	cellular_component	pICln-Sm protein complex
l	0043186	cellular_component	P granule
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0071011	cellular_component	precatalytic spliceosome
l	1990904	cellular_component	ribonucleoprotein complex
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0000974	cellular_component	Prp19 complex
L	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
L	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
L	0003677	molecular_function	DNA binding
L	0005634	cellular_component	nucleus
L	0005681	cellular_component	spliceosomal complex
L	0006281	biological_process	DNA repair
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006397	biological_process	mRNA processing
L	0006974	biological_process	DNA damage response
L	0008380	biological_process	RNA splicing
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005681	cellular_component	spliceosomal complex
m	0005685	cellular_component	U1 snRNP
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0008380	biological_process	RNA splicing
m	0034715	cellular_component	pICln-Sm protein complex
m	0071013	cellular_component	catalytic step 2 spliceosome
m	0120114	cellular_component	Sm-like protein family complex
m	1990904	cellular_component	ribonucleoprotein complex
M	0000974	cellular_component	Prp19 complex
M	0005634	cellular_component	nucleus
M	0005681	cellular_component	spliceosomal complex
M	0006397	biological_process	mRNA processing
M	0008380	biological_process	RNA splicing
M	0071013	cellular_component	catalytic step 2 spliceosome
M	0071014	cellular_component	post-mRNA release spliceosomal complex
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0005634	cellular_component	nucleus
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005689	cellular_component	U12-type spliceosomal complex
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006397	biological_process	mRNA processing
n	0008380	biological_process	RNA splicing
n	0034719	cellular_component	SMN-Sm protein complex
n	0043186	cellular_component	P granule
n	0071004	cellular_component	U2-type prespliceosome
n	0071011	cellular_component	precatalytic spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0097526	cellular_component	spliceosomal tri-snRNP complex
n	1990904	cellular_component	ribonucleoprotein complex
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0005634	cellular_component	nucleus
N	0005681	cellular_component	spliceosomal complex
N	0006397	biological_process	mRNA processing
N	0008380	biological_process	RNA splicing
o	0000389	biological_process	mRNA 3'-splice site recognition
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005686	cellular_component	U2 snRNP
o	0030620	molecular_function	U2 snRNA binding
o	0040022	biological_process	feminization of hermaphroditic germ-line
o	0051729	biological_process	germline cell cycle switching, mitotic to meiotic cell cycle
o	1990904	cellular_component	ribonucleoprotein complex
O	0000974	cellular_component	Prp19 complex
O	0003676	molecular_function	nucleic acid binding
O	0003723	molecular_function	RNA binding
O	0005634	cellular_component	nucleus
O	0005681	cellular_component	spliceosomal complex
O	0005737	cellular_component	cytoplasm
O	0006397	biological_process	mRNA processing
O	0008270	molecular_function	zinc ion binding
O	0008380	biological_process	RNA splicing
O	0017070	molecular_function	U6 snRNA binding
O	0036002	molecular_function	pre-mRNA binding
O	0046872	molecular_function	metal ion binding
O	0071006	cellular_component	U2-type catalytic step 1 spliceosome
O	0071007	cellular_component	U2-type catalytic step 2 spliceosome
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0003676	molecular_function	nucleic acid binding
p	0003723	molecular_function	RNA binding
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005681	cellular_component	spliceosomal complex
p	0005685	cellular_component	U1 snRNP
p	0006397	biological_process	mRNA processing
p	0008380	biological_process	RNA splicing
p	0030532	cellular_component	small nuclear ribonucleoprotein complex
p	0030619	molecular_function	U1 snRNA binding
p	1990904	cellular_component	ribonucleoprotein complex
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003723	molecular_function	RNA binding
P	0005634	cellular_component	nucleus
P	0005681	cellular_component	spliceosomal complex
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0045292	biological_process	mRNA cis splicing, via spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
PX	0000390	biological_process	spliceosomal complex disassembly
PX	0000398	biological_process	mRNA splicing, via spliceosome
PX	0003677	molecular_function	DNA binding
PX	0005634	cellular_component	nucleus
PX	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0000974	cellular_component	Prp19 complex
q	0004842	molecular_function	ubiquitin-protein transferase activity
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005681	cellular_component	spliceosomal complex
q	0005737	cellular_component	cytoplasm
q	0006281	biological_process	DNA repair
q	0006397	biological_process	mRNA processing
q	0006974	biological_process	DNA damage response
q	0008380	biological_process	RNA splicing
q	0016567	biological_process	protein ubiquitination
q	0016740	molecular_function	transferase activity
q	0030154	biological_process	cell differentiation
q	0061630	molecular_function	ubiquitin protein ligase activity
q	0070534	biological_process	protein K63-linked ubiquitination
q	0071006	cellular_component	U2-type catalytic step 1 spliceosome
q	0071028	biological_process	nuclear mRNA surveillance
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0003729	molecular_function	mRNA binding
Q	0004386	molecular_function	helicase activity
Q	0005634	cellular_component	nucleus
Q	0005681	cellular_component	spliceosomal complex
Q	0006397	biological_process	mRNA processing
Q	0008380	biological_process	RNA splicing
Q	0071013	cellular_component	catalytic step 2 spliceosome
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0000974	cellular_component	Prp19 complex
r	0004842	molecular_function	ubiquitin-protein transferase activity
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005681	cellular_component	spliceosomal complex
r	0005737	cellular_component	cytoplasm
r	0006281	biological_process	DNA repair
r	0006397	biological_process	mRNA processing
r	0006974	biological_process	DNA damage response
r	0008380	biological_process	RNA splicing
r	0016567	biological_process	protein ubiquitination
r	0016740	molecular_function	transferase activity
r	0030154	biological_process	cell differentiation
r	0061630	molecular_function	ubiquitin protein ligase activity
r	0070534	biological_process	protein K63-linked ubiquitination
r	0071006	cellular_component	U2-type catalytic step 1 spliceosome
r	0071028	biological_process	nuclear mRNA surveillance
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0002119	biological_process	nematode larval development
R	0005515	molecular_function	protein binding
R	0005681	cellular_component	spliceosomal complex
R	0007281	biological_process	germ cell development
R	0009792	biological_process	embryo development ending in birth or egg hatching
R	0010468	biological_process	regulation of gene expression
R	0018991	biological_process	egg-laying behavior
R	0040011	biological_process	locomotion
R	0040025	biological_process	vulval development
R	0042303	biological_process	molting cycle
R	0045893	biological_process	positive regulation of DNA-templated transcription
R	0060065	biological_process	uterus development
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0000974	cellular_component	Prp19 complex
s	0004842	molecular_function	ubiquitin-protein transferase activity
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005681	cellular_component	spliceosomal complex
s	0005737	cellular_component	cytoplasm
s	0006281	biological_process	DNA repair
s	0006397	biological_process	mRNA processing
s	0006974	biological_process	DNA damage response
s	0008380	biological_process	RNA splicing
s	0016567	biological_process	protein ubiquitination
s	0016740	molecular_function	transferase activity
s	0030154	biological_process	cell differentiation
s	0061630	molecular_function	ubiquitin protein ligase activity
s	0070534	biological_process	protein K63-linked ubiquitination
s	0071006	cellular_component	U2-type catalytic step 1 spliceosome
s	0071028	biological_process	nuclear mRNA surveillance
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0000413	biological_process	protein peptidyl-prolyl isomerization
S	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0006457	biological_process	protein folding
S	0016853	molecular_function	isomerase activity
S	0071013	cellular_component	catalytic step 2 spliceosome
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0000974	cellular_component	Prp19 complex
t	0004842	molecular_function	ubiquitin-protein transferase activity
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005681	cellular_component	spliceosomal complex
t	0005737	cellular_component	cytoplasm
t	0006281	biological_process	DNA repair
t	0006397	biological_process	mRNA processing
t	0006974	biological_process	DNA damage response
t	0008380	biological_process	RNA splicing
t	0016567	biological_process	protein ubiquitination
t	0016740	molecular_function	transferase activity
t	0030154	biological_process	cell differentiation
t	0061630	molecular_function	ubiquitin protein ligase activity
t	0070534	biological_process	protein K63-linked ubiquitination
t	0071006	cellular_component	U2-type catalytic step 1 spliceosome
t	0071028	biological_process	nuclear mRNA surveillance
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0000974	cellular_component	Prp19 complex
T	0071013	cellular_component	catalytic step 2 spliceosome
TF	0000390	biological_process	spliceosomal complex disassembly
TF	0003676	molecular_function	nucleic acid binding
TF	0005634	cellular_component	nucleus
TF	0005681	cellular_component	spliceosomal complex
TF	0006397	biological_process	mRNA processing
TF	0008380	biological_process	RNA splicing
TF	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0003729	molecular_function	mRNA binding
W	0005634	cellular_component	nucleus
W	0005681	cellular_component	spliceosomal complex
W	0006397	biological_process	mRNA processing
W	0008380	biological_process	RNA splicing
W	0071013	cellular_component	catalytic step 2 spliceosome
y	0000413	biological_process	protein peptidyl-prolyl isomerization
y	0003676	molecular_function	nucleic acid binding
y	0003723	molecular_function	RNA binding
y	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
y	0004518	molecular_function	nuclease activity
y	0005515	molecular_function	protein binding
y	0005737	cellular_component	cytoplasm
y	0006309	biological_process	apoptotic DNA fragmentation
y	0006457	biological_process	protein folding
y	0006915	biological_process	apoptotic process
y	0016018	molecular_function	cyclosporin A binding
y	0016853	molecular_function	isomerase activity
y	0071013	cellular_component	catalytic step 2 spliceosome
Z	0005684	cellular_component	U2-type spliceosomal complex
Z	0071014	cellular_component	post-mRNA release spliceosomal complex

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YngTiFHRIIadFMiQGG

Chain	Residue	Details
S	TYR46-GLY63
y	TYR183-GLY200

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVTCarDsTARVWDM

Chain	Residue	Details
T	LEU283-MET297
T	VAL325-LEU339
E	LEU53-VAL67
E	LEU96-MET110
E	VAL180-MET194
E	ILE272-THR286
q	LEU395-LEU409

---

site_id	PS00997
Number of Residues	23
Details	G10_1 G10 protein signature 1. LCCvKCvntrDsNfgtaCiCRVP

Chain	Residue	Details
N	LEU103-PRO125

---

site_id	PS00998
Number of Residues	10
Details	G10_2 G10 protein signature 2. CvHCGCHGCS

Chain	Residue	Details
N	CYS137-SER146

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	131
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	491
Details	Region: {"description":"Reverse transcriptase homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	13
Details	Region: {"description":"Important for branch point selection","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	171
Details	Region: {"description":"Restriction endonuclease homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	253
Details	Region: {"description":"RNase H homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	83
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	183
Details	Domain: {"description":"Helicase ATP-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	217
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	303
Details	Domain: {"description":"SEC63 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	175
Details	Domain: {"description":"Helicase ATP-binding 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	312
Details	Domain: {"description":"SEC63 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	Motif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	94
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	9
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	582
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	14
Details	Compositional bias: {"description":"Gly residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	21
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	21
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	21
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	21
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	38
Details	Domain: {"description":"LRRCT"}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	142
Details	Domain: {"description":"U-box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	39
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	39
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	39
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	39
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	39
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	30
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---