8RMM
Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, S (A, B, K) | Calcium homeostasis modulator protein 4 | polymer | 322 | 35981.7 | 3 | UniProt (Q5JW98) Pfam (PF14798) | Homo sapiens (human) | Protein FAM26D |
| 2 | B, D, T (L, M, U) | Synthetic nanobody SbC4 | polymer | 119 | 12877.4 | 3 | synthetic construct | ||
| 3 | E, F, H, J, L... (C, D, E, F, G...) | Calcium homeostasis modulator protein 2 | polymer | 331 | 37099.5 | 8 | UniProt (Q9HA72) Pfam (PF14798) | Homo sapiens (human) | Protein FAM26B |
| 4 | G, I, K, M, O... (O, P, Q, R, S...) | Synthetic nanobody SbC2 | polymer | 130 | 14067.5 | 7 | synthetic construct | ||
| 5 | AA, V, W, X, Y... (I, D, E, F, G...) | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 6 | Chemie (PLC) |
Sequence modifications
A, B, K: 2 - 314 (UniProt: Q5JW98)
C, D, E, F, G, H, I, J: 2 - 323 (UniProt: Q9HA72)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ser 1 | - | expression tag |
| Ala 315 | - | expression tag |
| Leu 316 | - | expression tag |
| Glu 317 | - | expression tag |
| Val 318 | - | expression tag |
| Leu 319 | - | expression tag |
| Phe 320 | - | expression tag |
| Gln 321 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ser 1 | - | expression tag |
| Ala 324 | - | expression tag |
| Leu 325 | - | expression tag |
| Glu 326 | - | expression tag |
| Val 327 | - | expression tag |
| Leu 328 | - | expression tag |
| Phe 329 | - | expression tag |
| Gln 330 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 21 |
| Total formula weight | 541845.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3737.0 | |
| All* | Total formula weight | 545582.5 |
