8RMM
Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4
Functional Information from PROSITE/UniProt
| site_id | PS01186 |
| Number of Residues | 15 |
| Details | EGF_2 EGF-like domain signature 2. CsCapPYrrisple.C |
| Chain | Residue | Details |
| A | CYS83-CYS97 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 168 |
| Details | TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV |
| Chain | Residue | Details |
| C | MET22-ALA43 | |
| D | MET22-ALA43 | |
| E | MET22-ALA43 | |
| F | MET22-ALA43 | |
| G | MET22-ALA43 | |
| H | MET22-ALA43 | |
| I | MET22-ALA43 | |
| J | MET22-ALA43 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 432 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| C | PHE44-ARG52 | |
| G | SER133-ARG179 | |
| H | PHE44-ARG52 | |
| H | SER133-ARG179 | |
| I | PHE44-ARG52 | |
| I | SER133-ARG179 | |
| J | PHE44-ARG52 | |
| J | SER133-ARG179 | |
| C | SER133-ARG179 | |
| D | PHE44-ARG52 | |
| D | SER133-ARG179 | |
| E | PHE44-ARG52 | |
| E | SER133-ARG179 | |
| F | PHE44-ARG52 | |
| F | SER133-ARG179 | |
| G | PHE44-ARG52 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 184 |
| Details | TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV |
| Chain | Residue | Details |
| C | ASN53-ASN76 | |
| D | ASN53-ASN76 | |
| E | ASN53-ASN76 | |
| F | ASN53-ASN76 | |
| G | ASN53-ASN76 | |
| H | ASN53-ASN76 | |
| I | ASN53-ASN76 | |
| J | ASN53-ASN76 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1120 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| C | ASN77-LEU101 | |
| G | HIS207-SER323 | |
| H | ASN77-LEU101 | |
| H | HIS207-SER323 | |
| I | ASN77-LEU101 | |
| I | HIS207-SER323 | |
| J | ASN77-LEU101 | |
| J | HIS207-SER323 | |
| C | HIS207-SER323 | |
| D | ASN77-LEU101 | |
| D | HIS207-SER323 | |
| E | ASN77-LEU101 | |
| E | HIS207-SER323 | |
| F | ASN77-LEU101 | |
| F | HIS207-SER323 | |
| G | ASN77-LEU101 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV |
| Chain | Residue | Details |
| C | LEU102-LEU132 | |
| D | LEU102-LEU132 | |
| E | LEU102-LEU132 | |
| F | LEU102-LEU132 | |
| G | LEU102-LEU132 | |
| H | LEU102-LEU132 | |
| I | LEU102-LEU132 | |
| J | LEU102-LEU132 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 208 |
| Details | TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV |
| Chain | Residue | Details |
| C | LEU180-LYS206 | |
| D | LEU180-LYS206 | |
| E | LEU180-LYS206 | |
| F | LEU180-LYS206 | |
| G | LEU180-LYS206 | |
| H | LEU180-LYS206 | |
| I | LEU180-LYS206 | |
| J | LEU180-LYS206 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | SITE: Not N-glycosylated => ECO:0000269|PubMed:31776515 |
| Chain | Residue | Details |
| C | ASN168 | |
| D | ASN168 | |
| E | ASN168 | |
| F | ASN168 | |
| G | ASN168 | |
| H | ASN168 | |
| I | ASN168 | |
| J | ASN168 |
