8RMK
Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, D, E, F... (A, B, C, D, E...) | Calcium homeostasis modulator protein 2 | polymer | 331 | 37099.5 | 11 | UniProt (Q9HA72) Pfam (PF14798) | Homo sapiens (human) | Protein FAM26B |
| 2 | B, M, N, O, P... (L, M, N, O, P...) | Synthetic nanobody SbC2 | polymer | 154 | 16803.3 | 11 | synthetic construct | ||
| 3 | AA, BA, CA, DA, EA... (E, F, G, H, I...) | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 11 | Chemie (PLC) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K: 2 - 323 (UniProt: Q9HA72)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ser 1 | - | expression tag |
| Ala 324 | - | expression tag |
| Leu 325 | - | expression tag |
| Glu 326 | - | expression tag |
| Val 327 | - | expression tag |
| Leu 328 | - | expression tag |
| Phe 329 | - | expression tag |
| Gln 330 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 22 |
| Total formula weight | 592931.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 6851.2 | |
| All* | Total formula weight | 599782.8 |
