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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8RMK

Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2

Functional Information from GO Data
ChainGOidnamespacecontents
A0005261molecular_functionmonoatomic cation channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0034220biological_processmonoatomic ion transmembrane transport
A0043065biological_processpositive regulation of apoptotic process
A0048167biological_processregulation of synaptic plasticity
A0070509biological_processcalcium ion import
A0098655biological_processmonoatomic cation transmembrane transport
A1903978biological_processregulation of microglial cell activation
A1904669biological_processATP export
B0005261molecular_functionmonoatomic cation channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0034220biological_processmonoatomic ion transmembrane transport
B0043065biological_processpositive regulation of apoptotic process
B0048167biological_processregulation of synaptic plasticity
B0070509biological_processcalcium ion import
B0098655biological_processmonoatomic cation transmembrane transport
B1903978biological_processregulation of microglial cell activation
B1904669biological_processATP export
C0005261molecular_functionmonoatomic cation channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0034220biological_processmonoatomic ion transmembrane transport
C0043065biological_processpositive regulation of apoptotic process
C0048167biological_processregulation of synaptic plasticity
C0070509biological_processcalcium ion import
C0098655biological_processmonoatomic cation transmembrane transport
C1903978biological_processregulation of microglial cell activation
C1904669biological_processATP export
D0005261molecular_functionmonoatomic cation channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0034220biological_processmonoatomic ion transmembrane transport
D0043065biological_processpositive regulation of apoptotic process
D0048167biological_processregulation of synaptic plasticity
D0070509biological_processcalcium ion import
D0098655biological_processmonoatomic cation transmembrane transport
D1903978biological_processregulation of microglial cell activation
D1904669biological_processATP export
E0005261molecular_functionmonoatomic cation channel activity
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0034220biological_processmonoatomic ion transmembrane transport
E0043065biological_processpositive regulation of apoptotic process
E0048167biological_processregulation of synaptic plasticity
E0070509biological_processcalcium ion import
E0098655biological_processmonoatomic cation transmembrane transport
E1903978biological_processregulation of microglial cell activation
E1904669biological_processATP export
F0005261molecular_functionmonoatomic cation channel activity
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0034220biological_processmonoatomic ion transmembrane transport
F0043065biological_processpositive regulation of apoptotic process
F0048167biological_processregulation of synaptic plasticity
F0070509biological_processcalcium ion import
F0098655biological_processmonoatomic cation transmembrane transport
F1903978biological_processregulation of microglial cell activation
F1904669biological_processATP export
G0005261molecular_functionmonoatomic cation channel activity
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0034220biological_processmonoatomic ion transmembrane transport
G0043065biological_processpositive regulation of apoptotic process
G0048167biological_processregulation of synaptic plasticity
G0070509biological_processcalcium ion import
G0098655biological_processmonoatomic cation transmembrane transport
G1903978biological_processregulation of microglial cell activation
G1904669biological_processATP export
H0005261molecular_functionmonoatomic cation channel activity
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0034220biological_processmonoatomic ion transmembrane transport
H0043065biological_processpositive regulation of apoptotic process
H0048167biological_processregulation of synaptic plasticity
H0070509biological_processcalcium ion import
H0098655biological_processmonoatomic cation transmembrane transport
H1903978biological_processregulation of microglial cell activation
H1904669biological_processATP export
I0005261molecular_functionmonoatomic cation channel activity
I0005886cellular_componentplasma membrane
I0006811biological_processmonoatomic ion transport
I0034220biological_processmonoatomic ion transmembrane transport
I0043065biological_processpositive regulation of apoptotic process
I0048167biological_processregulation of synaptic plasticity
I0070509biological_processcalcium ion import
I0098655biological_processmonoatomic cation transmembrane transport
I1903978biological_processregulation of microglial cell activation
I1904669biological_processATP export
J0005261molecular_functionmonoatomic cation channel activity
J0005886cellular_componentplasma membrane
J0006811biological_processmonoatomic ion transport
J0034220biological_processmonoatomic ion transmembrane transport
J0043065biological_processpositive regulation of apoptotic process
J0048167biological_processregulation of synaptic plasticity
J0070509biological_processcalcium ion import
J0098655biological_processmonoatomic cation transmembrane transport
J1903978biological_processregulation of microglial cell activation
J1904669biological_processATP export
K0005261molecular_functionmonoatomic cation channel activity
K0005886cellular_componentplasma membrane
K0006811biological_processmonoatomic ion transport
K0034220biological_processmonoatomic ion transmembrane transport
K0043065biological_processpositive regulation of apoptotic process
K0048167biological_processregulation of synaptic plasticity
K0070509biological_processcalcium ion import
K0098655biological_processmonoatomic cation transmembrane transport
K1903978biological_processregulation of microglial cell activation
K1904669biological_processATP export
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues594
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues253
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues264
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues330
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues286
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues77
DetailsRegion: {"description":"Hemichannel docking","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31988524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues407
DetailsRegion: {"description":"Intersubunit interaction","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UIV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues11
DetailsSite: {"description":"Not N-glycosylated","evidences":[{"source":"PubMed","id":"31776515","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2025-12-24

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