8RMK
Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 231 |
| Details | TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV |
| Chain | Residue | Details |
| A | MET22-ALA43 | |
| J | MET22-ALA43 | |
| K | MET22-ALA43 | |
| B | MET22-ALA43 | |
| C | MET22-ALA43 | |
| D | MET22-ALA43 | |
| E | MET22-ALA43 | |
| F | MET22-ALA43 | |
| G | MET22-ALA43 | |
| H | MET22-ALA43 | |
| I | MET22-ALA43 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 594 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | PHE44-ARG52 | |
| E | SER133-ARG179 | |
| F | PHE44-ARG52 | |
| F | SER133-ARG179 | |
| G | PHE44-ARG52 | |
| G | SER133-ARG179 | |
| H | PHE44-ARG52 | |
| H | SER133-ARG179 | |
| I | PHE44-ARG52 | |
| I | SER133-ARG179 | |
| J | PHE44-ARG52 | |
| A | SER133-ARG179 | |
| J | SER133-ARG179 | |
| K | PHE44-ARG52 | |
| K | SER133-ARG179 | |
| B | PHE44-ARG52 | |
| B | SER133-ARG179 | |
| C | PHE44-ARG52 | |
| C | SER133-ARG179 | |
| D | PHE44-ARG52 | |
| D | SER133-ARG179 | |
| E | PHE44-ARG52 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 253 |
| Details | TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV |
| Chain | Residue | Details |
| A | ASN53-ASN76 | |
| J | ASN53-ASN76 | |
| K | ASN53-ASN76 | |
| B | ASN53-ASN76 | |
| C | ASN53-ASN76 | |
| D | ASN53-ASN76 | |
| E | ASN53-ASN76 | |
| F | ASN53-ASN76 | |
| G | ASN53-ASN76 | |
| H | ASN53-ASN76 | |
| I | ASN53-ASN76 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1540 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | ASN77-LEU101 | |
| E | HIS207-SER323 | |
| F | ASN77-LEU101 | |
| F | HIS207-SER323 | |
| G | ASN77-LEU101 | |
| G | HIS207-SER323 | |
| H | ASN77-LEU101 | |
| H | HIS207-SER323 | |
| I | ASN77-LEU101 | |
| I | HIS207-SER323 | |
| J | ASN77-LEU101 | |
| A | HIS207-SER323 | |
| J | HIS207-SER323 | |
| K | ASN77-LEU101 | |
| K | HIS207-SER323 | |
| B | ASN77-LEU101 | |
| B | HIS207-SER323 | |
| C | ASN77-LEU101 | |
| C | HIS207-SER323 | |
| D | ASN77-LEU101 | |
| D | HIS207-SER323 | |
| E | ASN77-LEU101 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 330 |
| Details | TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV |
| Chain | Residue | Details |
| A | LEU102-LEU132 | |
| J | LEU102-LEU132 | |
| K | LEU102-LEU132 | |
| B | LEU102-LEU132 | |
| C | LEU102-LEU132 | |
| D | LEU102-LEU132 | |
| E | LEU102-LEU132 | |
| F | LEU102-LEU132 | |
| G | LEU102-LEU132 | |
| H | LEU102-LEU132 | |
| I | LEU102-LEU132 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 286 |
| Details | TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:31776515, ECO:0007744|PDB:6UIV |
| Chain | Residue | Details |
| A | LEU180-LYS206 | |
| J | LEU180-LYS206 | |
| K | LEU180-LYS206 | |
| B | LEU180-LYS206 | |
| C | LEU180-LYS206 | |
| D | LEU180-LYS206 | |
| E | LEU180-LYS206 | |
| F | LEU180-LYS206 | |
| G | LEU180-LYS206 | |
| H | LEU180-LYS206 | |
| I | LEU180-LYS206 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 11 |
| Details | SITE: Not N-glycosylated => ECO:0000269|PubMed:31776515 |
| Chain | Residue | Details |
| A | ASN168 | |
| J | ASN168 | |
| K | ASN168 | |
| B | ASN168 | |
| C | ASN168 | |
| D | ASN168 | |
| E | ASN168 | |
| F | ASN168 | |
| G | ASN168 | |
| H | ASN168 | |
| I | ASN168 |
