8RHT
Crystal Structure of Trypanosoma brucei DHFR in complex with the cofactor and inhibitor P25
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 244 | 26589.8 | 1 | UniProt (Q27783) | Trypanosoma brucei brucei | DHFR-TS |
| 2 | B (A) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 3 | C (A) | 4,4,7,8-tetramethyl-10~{H}-[1,3,5]triazino[1,2-a]benzimidazol-2-amine | non-polymer | 243.3 | 1 | Chemie (A1H0S) | |||
| 4 | D (A) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 1 - 241 (UniProt: Q27783)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26589.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 988.7 | |
| All* | Total formula weight | 27578.5 |
